CD274 Molecule (CD274) antibody (Biotin)

Antigen: CD274 Molecule (CD274)

Synonyms: B7-H, B7H1, PDL1, PD-L1, PDCD1L1, PDCD1LG1, MGC142294, MGC142296, B7h1, Pdl1, Pdcd1l1, Pdcd1lg1, A530045L16Rik, CD274

Clonality: Monoclonal (10F-9G2)

Host: Rat

Reactivity: Mouse (Murine)

Conjugate: Biotin

Application: Flow Cytometry (FACS)

Catalog no.: ABIN312295

Additional Information

Alternative name: CD274 (B7-H1, PDL1)

Isotype: IgG2b kappa

Clone: 10F-9G2

Description: CD274, also known as B7-H1 or programmed death ligand (PDL1), is a 40 kD type I transmembrane protein memberof B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendriticcells, IFN-gamma activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able tocostimulate T cell growth and cytokine production.

Application Details

Application Notes: Each lot of this antibody is quality tested by immunofluorescent staining withflow cytometric analysis. For immunofluorescent staining, the suggested useof this reagent is approx. 0.5 ug per 106 cells in 100 ul volume. It is recommendedthat the reagent be titrated for optimal performance for each application.

Purification: The antibody was purified by affinity chromatography, and conjugated withbiotin under optimal conditions. The solution is free of unconjugated biotin.

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Storage: The antibody solution should be stored undiluted at 4 degrees C. Do not freeze.

Restrictions: For Research Use only