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Antibody
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anti-CD41 ITGA2B
CD41 (ITGA2B) antibody
| Antigen |
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| Synonyms |
GTA, CD41, GP2B, HPA3, CD41B, GPIIb |
| Clonality |
Monoclonal (HIP8) |
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Host
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Reactivity
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 Alternatives Human, Chimpanzee, Baboon, Cynomolgus, Rhesus Monkey
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Application
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Alternatives Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Blocking Antibody (Inhibition)
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| Catalog no. |
ABIN312622 |
| Quantity |
500 ug (Variants) |
| Price |
Product not available in this region.
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| Shipping to |
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Alternative name
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CD41
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Isotype
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IgG1, kappa (Matching secondary antibodies)
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Clone
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HIP8
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Description
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CD41 is a 125/25 kD alpha subunit of the gpIIb/IIIa (CD41/CD61) complex. CD41 is a heterodimer composed of a heavychain (gpIIbalpha) and light chain (gpIIbbeta) linked by a single disulfide bond. It is a member of the integrin family primarily expressed on platelets and megakaryocytes. CD41 has been reported to be involved with platelet aggregation and platelet attachment to the ECM. CD41/CD61 complex acts as the receptor for fibrinogen, fibronectin, Von Willebrand factor, and thrombin. The HIP8 antibody has been reported to block the activation of platelets by various stimuli,including collagen, and ADP.
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Application Notes
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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is approx 0.5 ug per 106 cells in 100 ul volume or 100 ul of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixedfrozen tissue sections, and blocking of platelet aggregation2.
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Purity
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LEAF Purified
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Purification
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The antibody was purified by affinity chromatography.
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Buffer
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Phosphate-buffered solution, pH 7.2, containing no preservative. 0.2 um filtersterilized. Endotoxin level is < 0.1 EU/ug of the protein (< 0.01 ng/ug of theprotein) as determined by the LAL test.
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Storage
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The antibody solution should be stored undiluted at 4 degrees C.
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Restrictions
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For Research Use only
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Alternatives for antigen "CD41 (ITGA2B)", type "Antibodies"
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Hosts
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Mouse (19), Rat (4)
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Reactivities
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Human (19), Mouse (Murine) (4)
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Applications
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Flow Cytometry (FACS) (20), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1), Immunoprecipitation (IP) (1)
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Conjugates
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Biotin (4), FITC (4), RPE (3), APC (2), Alexa Fluor 488 (1), Alexa Fluor 700 (1), PE (1), Pacific Blue (1), PerCP (1)
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