Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7) antibody (PE)

Antigen: Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7)

Synonyms: p75, QA79, AIRM1, CD328, CDw328, D-siglec, SIGLEC-7, p75/AIRM1, SIGLEC7

Clonality: Polyclonal

Host: Please enquire

Reactivity: Human

Conjugate: PE

Application: Flow Cytometry (FACS)

Catalog no.: ABIN312866

Additional Information

Alternative name: CD328 (Siglec-7)

Isotype: IgG1, kappa chain

Clone: 6-434

Description: Siglec-7 is a 75 kD type I transmembrane protein and a member of the family of sialic acid-bindingimmunoglobulin-like lectins (Siglecs), also known as p75/AIRM1. It is primarily found on NK cells and monocytes. Thecytoplasmic domain of Siglec-7 contains immunoreceptor tyrosine-based inhibitory motif (ITIM). CD328 mediatessialic acid-dependent cell-cell binding and functions as an inhibitory receptor of NK cells. CD328 preferentially bindsto sialylated glycans with alpha2,8 disialyl and alpha2,6 sialyl residues.

Application Details

Application Notes: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is 20 ul per million cells or 20 ul per 100 ul of wholeblood. It is recommended that the reagent be titrated for optimal performance for each application.

Purification: The antibody was purified by affinity chromatography, and conjugated withPE under optimal conditions. The solution is free of unconjugated PE andunconjugated antibody.

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and0.2% (w/v) BSA (origin USA).

Storage: The antibody solution should be stored undiluted at 4 degrees C and protected from prolonged exposure to light. Do not freeze.

Restrictions: For Research Use only