Complement Decay-Accelerating Factor (CD55) antibody (PE/Cy7)

Antigen: Complement Decay-Accelerating Factor (CD55)

Synonyms: CR, TC, DAF, CROM

Clonality: Monoclonal (JS11)

Host: Mouse

Reactivity: Human

Conjugate: PE,Cy7

Application: Flow Cytometry (FACS)

Catalog no.: ABIN313179

Additional Information

Alternative name: CD55

Isotype: IgG1, kappa chain

Clone: JS11

Description: CD55 is a 60-70 kD glycosylphosphatidylinositol (GPI)-anchored single chain glycoprotein also known asdecay-accelerating factor (DAF). It is expressed on hematopoietic cells including erythrocytes and manynon-hematopoietic cells. CD55 accelerates the dissociation of the components of the C3-convertases (namely C2afrom C4b in the C4bC2a complex, a C3-convertase of the classical pathway, and factor Bb from the C3bBb complex,a C3-convertase of the alternative pathway) to protect cells from inappropriate damage caused by autologouscomplement. CD55 has been reported to reduce the efficiency of NK cell lysis and induce signal transduction in Tcells. CD55 has also been shown to interact with CD97 and bind to Coxsackie and Echovirus.

Application Details

Application Notes: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is 20 ul per million cells or 20 ul per 100 ul of wholeblood. It is recommended that the reagent be titrated for optimal performance for each application.

Purification: The antibody was purified by affinity chromatography, and conjugated withPE/Cy7 under optimal conditions. The solution is free of unconjugatedPE/Cy7 and unconjugated antibody.

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and0.2% (w/v) BSA (origin USA).

Storage: The antibody solution should be stored undiluted at 4 degrees C and protected from prolonged exposure to light. Do not freeze.

Restrictions: For Research Use only

Images

anti-Complement Decay-Accelerating Factor (CD55) antibody (PE/Cy7)