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Antibodies
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anti-Adducin 1 (Alpha) (ADD1) (Thr455) antibody
Adducin 1 (Alpha) (ADD1) (Thr455) antibody
| Antigen |
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| Synonyms |
ADDA, MGC3339, MGC44427, AI256389, MGC124621, ADD1, cb787, bZ1H20.1, MGC158352, zgc:158352, DKFZp459A0431, add1-a, add2, adda, MGC69376 |
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Epitope
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| Clonality |
Polyclonal |
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Host
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Reactivity
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Application
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| Catalog no. |
ABIN313775 |
| Quantity |
25 ul (Variants) |
| Price |
Product not available in this region.
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| Shipping to |
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Alternative name
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alpha-Adducin-Phosphorylated (Thr455)
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Immunogen
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Peptide-KLH
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Format
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Purified
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Isotype
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IgG (Matching secondary antibodies)
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Clone
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Poly6321
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Description
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The alpha-adducin protein is a ubiquitously expressed cytoskeletal protein thatbinds with high affinity to Ca2+/calmodulin and acts as a substrate for proteinkinases A and C. alpha-addducin is a 80-120 kD member of the aldolase class IIfamily and adducin subfamily. This protein has three isoforms that interact asheterodimers alpha/beta, and alpha/gamma. The molecular weights for the various isoforms arealpha=120 kD, beta=110kD, gamma=80kD. This protein has been reported to promote theassembly of the spectrin-actin network. Polymorphisms in alpha-adducin areassociated with cardiovascular disease and hypertension. alpha-adducin hasbeen reported to interact with calmodulin. When phosphorylated byRho-kinase, alpha-adducin can regulate membrane ruffling and cell motility. ThePoly6321 antibody has been shown to be useful for immunofluorescencemicroscopy of mouse and human alpha-adducin protein.
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Application Notes
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Each lot of this antibody is quality control tested by immunofluorescencestaining. For immunofluorescence microscopy: Use a dilution range of1:100~1:400. It is recommended that the reagent be titrated for optimalperformance for each application.
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Purification
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The antibody was purified by antigen-affinity chromatography.
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Buffer
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This antibody is provided in phosphate-buffered solution, pH 7.2, containing0.09% sodium azide and 50% glycerol.
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Storage
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Upon receipt, store frozen at -20 degrees C.
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Restrictions
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For Research Use only
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Alternatives for antigen "Adducin 1 (Alpha) (ADD1)", type "Antibodies"
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Hosts
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Rabbit (29), Mouse (3)
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Reactivities
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Human (31), Mouse (Murine) (23), Rat (Rattus) (23)
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Applications
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Western Blotting (WB) (30), Immunofluorescence (IF) (21), Immunohistochemistry (IHC) (17), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (12), ELISA (5), Enzyme Immunoassay (EIA) (3), Immunoprecipitation (IP) (3), ELISA (Detection) (1), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)
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Epitopes
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pSer726 (8), Ab-726 (5)
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Alternatives 
