5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase (ATIC) antibody

Antigen: 5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase (ATIC)

Clonality: Monoclonal (F38P7H9)

Host: Mouse

Reactivity: Human, Mouse (Murine), Rat (Rattus), Frog, Fruit Fly (Drosophila melanogaster)

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Catalog no.: ABIN313781

Additional Information

Alternative name: ATIC

Immunogen: Ovalbumin-conjugated synthetic Peptide AHTNLRLFHH

Format: Purified

Isotype: IgG1, kappa  (Matching secondary antibodies)

Clone: F38P7H9

Description: ATIC (AICAR transformylase/IMP cyclohydrolase) belongs to the purH family, expressed in the cytoplasm, predictedmolecular weight approximately 65 kD. ATIC catalyzes the penultimate and final steps in the de novo purinenucleotide biosynthesis pathway. ATIC acts as a bifunctional enzyme catalyze the formation of FAICAR and IMP.AICA-ribosiduria is a recently discovered inherited metabolic disease caused by a defect in final steps of purine denovo biosynthesis. Clone F38P7H9 has been shown to be useful for western blotting and immunohistochemistry ofhuman, mouse, rat, frog and fruit fly ATIC.

Application Details

Application Notes: Each lot of this antibody is quality control tested by Western blotting. ForWestern blotting, suggested working dilution(s): Use 5-10 ug per 5 mlantibody dilution buffer for each mini-gel. It is recommended that the reagentbe titrated for optimal performance for each application.

Purification: This antibody was purified by affinity chromatography.

Buffer: This antibody is provided in phosphate-buffered solution, pH 7.2, containing0.09% sodium azide at 0.5 mg/ml.

Storage: Upon receipt, store undiluted at 4 degrees C.

Restrictions: For Research Use only