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Antibody
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anti-CAK cdk7-Phosphorylated Ser164-Thr170
CAK (cdk7)-Phosphorylated (Ser164/Thr170) antibody
| Antigen |
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| Clonality |
Polyclonal |
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Host
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Rabbit
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Reactivity
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Human
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Application
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Immunofluorescence (IF)
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| Catalog no. |
ABIN313813 |
| Quantity |
25 ul (Variants) |
| Price |
Product not available in this region.
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| Shipping to |
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Immunogen
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Modified peptide
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Format
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Purified
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Isotype
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IgG (Matching secondary antibodies)
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Clone
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Poly6324
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Description
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CAK (also known as CDK-activating kinase, CDK7 and cell division protein kinase 7 is a 40 kD nuclear protein that isa member of the serine/threonine family of protein kinases, CDC2/CDKX subfamily. CAK activates cyclin-associatedkinases CDC2/CDK1, CDK2, CDK4, CDK6 by threonine phosphorylation and controls cell cycle progression, DNArepair, and RNA polymerase II transcription. CAK is activated by phosphorylation at Thr170 and is inactivated byphosphorylation at Ser164. CAK has been reported to interact with cyclin H and MAT1 to form the CAK complex, theCAK complex then interacts with core-TFIIH to form the TFIIH basal transcription factor. The Poly6324 antibody isuseful for immunofluorescence microscopy of human CAK protein.
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Application Notes
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Each lot of this antibody is quality control tested by immunofluorescence staining. For immunofluorescencemicroscopy: Use a dilution range of 1:100~1:400. It is recommended that the reagent be titrated for optimalperformance for each application.
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Purification
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The antibody was purified by antigen-affinity chromatography.
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Buffer
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This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 50% glycerol.
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Storage
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Upon receipt, store frozen at -20 degrees C.
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Restrictions
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For Research Use only
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