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Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) antibody

Antigen

Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3)
Synonyms
CC3, Lice, Yama, CPP32, Apopain, Caspase-3, A830040C14Rik, Cas3, Casp3, DECAY, Drosophila executioner caspase related to Apopain/Yama, caspase 3, DmelCG14902, CG14902, DRICE, ICE, DmelCG7788, CG7788,  ... show more
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Application
Alternatives Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
Catalog no. ABIN313817
Quantity 125 ul  (Variants)
Price Product not available in this region.
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Additional Information
Application Details Alternatives Secondary Antibodies Variants back to top

Alternative name Caspase 3
Immunogen Peptide mapping to the amino terminal domain of human caspase-3prescursor
Format Purified
Clone Poly6341
Description Caspase 3 is a member of the peptidase family C14. This cytoplasmic caspase functions as a heterotetramer and hastwo isoforms (one acts as a dominant negative inhibitor). The pro-form of this caspase is approximately 32 kD.Caspase 3 is involved in the caspase activation cascade responsible for apoptosis execution. Caspase 3 is inhibitedby c-IAP1, c-IAP2, XIAP, survivin, and Livin and activated by Caspase 6, -8 , and -10, granzyme B, Apaf-1 bycleavage into large p17 and small p12 subunits. Caspase 3 has been shown to cleave PARP, huntingtin, androgenreceptor, atrophin-1, DNA- PKcs, D4-GDI, hnRNPs C1/C2, U1snRNP, PKC delta, ATM, fodrin, gelsolin, ICAD, RIP,X-IAP, STAT1, topoisomerase I, vimentin, Rb, lamin B, mdm2, and beta-catenin. The poly6341 antibody has been shownto be useful for western blotting, immunoprecipitation and immunohistochemistry of human Human caspase-3precursor.
Synonyms CC3, Lice, Yama, CPP32, Apopain, Caspase-3, A830040C14Rik, Cas3, Casp3, DECAY, Drosophila executioner caspase related to Apopain/Yama, caspase 3, DmelCG14902, CG14902, DRICE, ICE, DmelCG7788, CG7788, casp3, xcpp32, CASP3

Application Details
Alternatives Secondary Antibodies Variants back to top

Application Notes Each lot of this antibody is quality control tested by Western blotting. Western blotting suggested working dilution(s): Use 25 ul per 5 ml antibodydilution buffer for each mini-gel. It is recommended that the reagent betitrated for optimal performance for each application.
Purification This antibody was purified by affinity chromatography.
Buffer This antibody is provided in phosphate-buffered solution, pH 7.2, containing0.09% sodium azide and 0.2% gelatin.
Storage The antibody solution should be stored undiluted at 4 degrees C. DO NOT FREEZE.
Restrictions For Research Use only

Alternatives
Application Details Secondary Antibodies Variants back to top

Alternatives for antigen "Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3)", type "Antibodies"
Hosts Rabbit (67), Mouse (19), Goat (3)
Reactivities Human (86), Mouse (Murine) (46), Rat (Rattus) (43), Dog (Canine) (25), Cow (Bovine) (22), Pig (Porcine) (22), Rabbit (22), Sheep (Ovine) (21), Horse (Equine) (15), Hamster (8), Monkey (6), Chicken (3), Gerbil (3), Guinea Pig (3), Yeast (Saccharomyces Cerevisiae) (3), Baboon (1)
Applications Western Blotting (WB) (65), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (27), Immunofluorescence (IF) (16), Flow Cytometry (FACS) (14), ELISA (13), Immunoprecipitation (IP) (12), Immunohistochemistry (IHC) (10), Enzyme Immunoassay (EIA) (6), Immunohistochemistry (Frozen Sections) (IHC (fro)) (3), Dot Blot (Dot) (2), Immunocytochemistry (ICC) (2), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), ELISA (Detection) (1), Immunoelectron Microscopy (EM) (1)
Conjugates Alexa Flour 488 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1), RBITC (1)
Epitopes active (18), Cleaved-Asp175 (3), Center (2), active + pro (2), AA 166-183 (1), Ab-150 (1), N-Term (1), active/cleaved (1), p17 (1), p17 Cleaved-Asp175 (1), p32/p17 not p11 (1), pSer150 (1)