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C-Fos antibody
| Antigen | C-Fos |
| Clonality | Polyclonal |
| Host |
 Alternatives Rabbit |
| Reactivity |
Alternatives Human, Rat (Rattus), Mouse (Murine) |
| Application |
Alternatives Western Blotting (WB)
|
| Catalog no. | ABIN313929 |
| Quantity | 25 ul (Variants) |
| Price | Product not available in this region. |
| Shipping to |
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Additional Information
| Immunogen | DMDLSGSFYAADWEC (aa. 291-304 of human c-Fos)Reactivity: HumanCross- |
| Format | Purified |
| Clone | Poly6414 |
| Description | The c-fos protein, also known as FBJ murine viral (v-fos) oncogene homolog , is a 62 kD cellular oncogene. The c-fosprotein contains a bZIP region with a DNA-binding domain and a leucine zipper domain. Together with c-jun, c-junproteins form the heterodimeric AP-1 complex that binds to the TRE elements of cellular and viral genes includingcollagenase, interleukin 2, stromelysin, SV40 and polyoma among others. c-fos is expressed in a variety of normaladult tissues and has been implicated as a critical transcription factor for skeletal formation and maintenance. Thistranscription factor is modified by phosphorylation by a number of upstream kinases and has been shown to interactwith a variety of other proteins involved in transcriptional regulation. c-fos has been implicated in the development offibrous bone dysplasia and osteosarcoma. The c-fos protein has been shown to interact with a variety of otherproteins including c-jun, TFIID, NCOA2, NFAT1, CHOP, ELK1, SRC1, and ETS1. The Poly6244 antibody recognizeshuman, rat, and mouse c-fos and has been shown to be useful for Western blotting, immunoprecipitation, andimmunohistochemistry. |
Application Details
| Application Notes | Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s):Use 10 ul per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimalperformance for each application. |
| Purification | The antibody was purified by antigen-affinity chromatography. |
| Buffer | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 50% glycerol. |
| Storage | Upon receipt, store at -20 degrees C. |
| Restrictions | For Research Use only |
Alternatives
Alternatives for antigen "C-Fos", type "Antibodies"
| Hosts | Rabbit (34), Mouse (8), Sheep (7) |
| Reactivities | Human (42), Rat (Rattus) (27), Mouse (Murine) (23), Pig (Porcine) (15), Hamster (3), Rabbit (3), Cat (Feline) (1), Dog (Canine) (1) |
| Applications | Western Blotting (WB) (31), Flow Cytometry (FACS) (15), Immunofluorescence (IF) (14), Enzyme Immunoassay (EIA) (9), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (8), ELISA (5), Immunohistochemistry (Frozen Sections) (IHC (fro)) (5), Immunohistochemistry (IHC) (5), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), Immunoprecipitation (IP) (2), Immunoelectron Microscopy (EM) (1) |
| Conjugates | Alexa Flour 488 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1), RBITC (1) |
| Epitopes | N-Term (3), pT232 (1) |
