Citron Kinase antibody

Antigen: Citron Kinase

Synonyms: CRIK, STK21, KIAA0949

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunofluorescence (IF)

Catalog no.: ABIN313933

Additional Information

Immunogen: Peptide corresponding to amino acids 62-74 of human citron kinase

Format: Purified

Isotype: IgG  (Matching secondary antibodies)

Clone: Poly6363

Description: Citron is a serine/threonine kinase belonging to the myotonic dystrophy kinase family. This kinase contains anAGC-kinase C-terminal domain, CNH domain, PH domain, phorbol-ester/DAG-type zinc finger, and protein kinasedomain. Citron kinase can be produced in at least two different isoforms: Citron Rho-interacting kinase (CRIK) andCRIK-short kinase (SK). CRIK is a 231 kD protein in which the kinase domain is followed by the sequence of Citron, apreviously identified Rho/Rac binding protein. SK is a ~54 kD protein which consists mostly of the kinase domain.Citron kinase binds to Rho-GTP and has been shown to be involved in the regulation of cytokinesis, control of G2/Mtransition in the hepatocyte cell cycle, and the development of the central nervous system. The Poly6363 antibodyrecognizes both human Citron Rho-interacting kinase (CRIK) and CRIK-short kinase (SK), and has been shown to beuseful for immunofluorescent staining.

Application Details

Application Notes: Each lot of this antibody is quality control tested by immunofluorescence staining. For immunofluorescencemicroscopy: Use a dilution range of 1:100~1:400. It is recommended that the reagent be titrated.

Purification: This antibody was purified by affinity chromatography.

Buffer: This antibody is provided in phosphate-buffered solution, pH 7.2, containing0.09% sodium azide and 50% glycerol.

Storage: Upon receipt, store frozen at -20 degrees C.

Restrictions: For Research Use only