Citron (Rho-Interacting, serine/threonine Kinase 21) (CIT) antibody

Antigen: Citron (Rho-Interacting, serine/threonine Kinase 21) (CIT)

Synonyms: CRIK, STK21, KIAA0949, CIT, crik, xcit, stk21

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunofluorescence (IF)

Catalog no.: ABIN313937

Additional Information

Alternative name: CRIK

Immunogen: Peptide-KLH, C-terminal

Format: Purified

Isotype: IgG  (Matching secondary antibodies)

Clone: Poly6364

Description: CRIK (Citron Rho-interacting kinase) is a serine/threonine kinase belonging to the myotonic dystrophy kinase family.This kinase contains an AGC-kinase C-terminal domain, CNH domain, PH domain, phorbol-ester/DAG-type zincfinger, and a protein kinase domain. Citron kinase can be produced in at least two different isoforms: CitronRho-interacting kinase (CRIK) and CRIK-short kinase (SK). CRIK is a 231 kD protein in which the kinase domain isfollowed by the sequence of Citron, a previously identified Rho/Rac binding protein. SK is a ~54 kD protein whichconsists mostly of the kinase domain. Citron kinase binds to Rho-GTP and has been shown to be involved in theregulation of cytokinesis, control of G2/M transition in the hepatocyte cell cycle, and the development of the centralnervous system. The Poly6364 antibody recognizes human CRIK and has been shown to be useful forimmunoflorence staining.

Application Details

Application Notes: Each lot of this antibody is quality control tested by immunofluorescence staining. For immunofluorescencemicroscopy: Use a dilution range of 1:100~1:400. It is recommended that the reagent be titrated.

Purification: This antibody was purified by affinity chromatography.

Buffer: This antibody is provided in phosphate-buffered solution, pH 7.2, containing0.09% sodium azide and 50% glycerol.

Storage: Upon receipt, store frozen at -20 degrees C.

Restrictions: For Research Use only