GLI1 antibody

Antigen: GLI1

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB)

Catalog no.: ABIN313984

Additional Information

Alternative name: Gli-1

Immunogen: Synthetic peptide 223-237 (REEKREPESVYETDC)

Format: Purified

Description: This gene encodes a protein which is a member of the Kruppel family of zinc finger proteins. The function of thisgene has not been determined, however, it may play a role in normal development gene transcription. The Glitranscription factors constitute the final effectors of the Hedgehog signalling pathway, which is critical to vertebratedevelopment. Mouse mutation studies indicate possible involvement in human foregut malformation. In addition, boththe Ras and Transforming Growth Factor Beta pathways also stimulate and/or induce Gli1 and Gli2 activityindependently of Hedgehog ligands.

Application Details

Application Notes: Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s):Use 0.5 to 2.0 ug/ml antibody dilution for each mini-gel. It is recommended that the reagent be titrated for optimalperformance for each application.

Purification: The antibody was purified by affinity chromatography.

Buffer: This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 50% glycerol.

Storage: Upon receipt, store frozen at -20 degrees C.

Restrictions: For Research Use only