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Jun Proto-Oncogene (JUN) (pTyr91/Tyr93) antibody
| Antigen | Jun Proto-Oncogene (JUN) |
| Synonyms | AP1, AP-1, c-Jun, fj36h07, zgc:65863, wu:fj36h07, jun |
| Epitope |
 Alternatives pTyr91/Tyr93 |
| Clonality | Monoclonal (C-J4C4-1) |
| Host |
Alternatives Mouse |
| Reactivity |
Alternatives Mouse (Murine), Rat (Rattus) |
| Application |
Alternatives Western Blotting (WB)
|
| Catalog no. | ABIN314077 |
| Quantity | 25 ug (Variants) |
| Price | Product not available in this region. |
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Additional Information
| Alternative name | Phospho-C-Jun (Tyr91/Tyr93) |
| Immunogen | Modified peptide conjugated to KLHReactivity: HumanCross- |
| Format | Purified |
| Isotype | IgG1, kappa chain (Matching secondary antibodies) |
| Clone | C-J4C4-1 |
| Description | C-Jun (also known as protooncogene c-jun) is a member of the b-ZIP transcription factor, jun subfamily, containing aleucine zipper domain. This nuclear protein is ubiquitously expressed and binds the enhancer heptamer motif5',-TGA(C/G)TCA-3', to activate gene expression. c-jun interacts with c-Fos to form a functionaltranscriptional dimer, Jun deletions and translocations have been observed in human malignancies. c-jun isphosphorylated by JNK1, casein kinase II, and DNA-dependent protein kinase, phosphorylation enhancestranscriptional activity. E1A binding protein p300 acetylates and decreases the transcriptional activity of c-jun. Thereare multiple phosphorylation sites (63, 73, 231, 249) on c-jun and one reported acetylation site (271). C-jun has beenreported to interact with CREB binding protein (CBP), CREB, ATF4, c-Fos, STAT1, STAT3 and STAT4, Bcl-3,SMAD3/4 heterodimers, and TCF20. The Poly6065 antibody recognizes mouse and human c-jun and has beenshown to be useful for Western blotting |
Application Details
| Application Notes | Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s):Use 5 ug antibody per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titratedfor optimal performance for each application. |
| Purification | The antibody was purified by protein G affinity chromatography |
| Buffer | This antibody is provided in phosphate-buffered solution, pH 7.2, containing0.09% sodium azide. Final antibody concentration is 0.5 mg/ml. |
| Storage | Upon receipt, store at 4 degrees C |
| Restrictions | For Research Use only |
Alternatives
Alternatives for antigen "Jun Proto-Oncogene (JUN)", type "Antibodies"
| Hosts | Rabbit (220), Mouse (4) |
| Reactivities | Human (216), Mouse (Murine) (146), Rat (Rattus) (129), Cow (Bovine) (2), Chicken (1), Dog (Canine) (1), Fruit Fly (Drosophila melanogaster) (1), Guinea Pig (1), Hamster (1), Monkey (1), Pig (Porcine) (1), Rabbit (1), Sheep (Ovine) (1), Xenopus laevis (1) |
| Applications | Western Blotting (WB) (206), Immunohistochemistry (IHC) (96), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (52), Enzyme Immunoassay (EIA) (47), ELISA (29), Immunofluorescence (IF) (19), Immunoprecipitation (IP) (19), Dot Blot (Dot) (14), Immunohistochemistry (Frozen Sections) (IHC (fro)) (10), ELISA (Detection) (3), Flow Cytometry (FACS) (1) |
| Epitopes | pSer73 (14), pSer63 (11), pThr239 (10), pTyr170 (10), pSer243 (8), pThr91 (8), pThr93 (8), Ab-239 (5), Ab-243 (5), Ab-91 (5), Ab-93 (5), pS63 (3), Ab 63 (2), C-Term (2), pS73 (2), S63 (1), S73 (1), Sumoylation Site (1), T239 (1), T243 (1), T249 (1), pT239 (1), pT243 (1), pT249 (1), pThr243 (1), pThr249 (1), pY170 (1) |
