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Presenilin (PSEN1/PSEN2) (pSer 353/Ser357) antibody
| Antigen | Presenilin (PSEN1/PSEN2) |
| Synonyms | pre1, psen, zfPS1, zf-PS1, CG5868, DPS, DPsn, DmPS, DrosPS, PS, PS1, l(3)77CDb, pres, psn, DmelCG18803, CG18803 |
| Epitope |
pSer 353/Ser357 |
| Clonality | Polyclonal |
| Host |
Rabbit |
| Reactivity |
Human |
| Application |
Immunofluorescence (IF)
|
| Catalog no. | ABIN314085 |
| Quantity | 25 ul (Variants) |
| Price | Product not available in this region. |
| Shipping to |
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Additional Information
| Alternative name | Phospho-presenilin (Ser 353/Ser357) |
| Immunogen | Modified peptide |
| Format | Purified |
| Isotype | IgG (Matching secondary antibodies) |
| Clone | Poly6366 |
| Description | Presenilin 1 belongs to the peptidase A22A family. Predicted molecular weight approximately 53 kD. Presenilinsassemble with nicastrin, PEN-2, and APH-1 into an active g-secretase complex responsible for proteolytic cleavage ofamyloid precursor protein (APP) and transmembrane cleavage of Notch receptor proteins. Presenilin 1 is subjected toan endoproteolytic cleavage, generating a stable heterodimer composed of an N-terminal and a C-terminal fragment.Presenilin 1 may play a role in intracellular signaling and gene expression or in linking chromatin to the nuclearmembrane and involved in stimulates cell-cell adhesion, negatively regulating Wnt signaling, and hematopoiesis.Presenilin1 residues Ser353 and Ser357 are phosphorylated by GSK-3beta. The Poly6366 antibody recognizes humanphospho-Presenilin 1 (Ser353/Ser357) and has been shown to be useful for immunoflorence staining. This antibodydoes not detect Presenilin 1 phosphorylated at other sites. |
Application Details
| Application Notes | Each lot of this antibody is quality control tested by immunofluorescence staining. For immunofluorescencemicroscopy: Use a dilution range of 1:100~1:400. It is recommended that the reagent be titrated. |
| Purification | The antibody was purified by antigen-affinity chromatography. |
| Buffer | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 50% glycerol. |
| Storage | Upon receipt, store frozen at -20 degrees C. |
| Restrictions | For Research Use only |
