RAR-Related Orphan Receptor gamma (RORC) antibody

Antigen: RAR-Related Orphan Receptor gamma (RORC)

Clonality: Monoclonal (4F3-3C8-2B7)

Host: Mouse

Reactivity: Mouse (Murine), Human

Application: Western Blotting (WB)

Catalog no.: ABIN314105

Additional Information

Alternative name: RORgamma

Immunogen: Human RORgamma-GST recombinant protein

Format: Purified

Isotype: IgG1, kappa chain  (Matching secondary antibodies)

Clone: 4F3-3C8-2B7

Description: RORgamma (Retinoid-related orphan receptor gamma) belongs to the nuclearhormone receptor family, NR1 subfamily. Contains 1 nuclear receptorDNA-binding domain. RORgamma has two isoforms: gamma1 and gamma2 (also referred to asRORgammat). The RORgammat differs from the RORgamma1 isoform in that it lacks the aminoterminus of RORgamma1. RORgamma1 contains 516 amino acids and RORgammat contains495 amino acids. RORgamma1 has a molecular weight of approximately 58 kD.RORgamma1 is highly expressed in thymus, kidney, liver, muscle, and brown fat butnot in white fat tissue. RORgammat is specifically expressed in only two cellpopulations, DP thymocytes and lymphoid tissue inducers (LTi). RORgamma playsa critical role in control apoptosis during thymopoiesis and T cellhomeostasis. RORgamma is to regulate TCRalpha repertoire by virtue of its positiveregulatory role on Bcl-x expression. RORgamma is essential for lymph nodes andPeyers patches development.

Application Details

Application Notes: Each lot of this antibody is quality control tested by Western blotting. Westernblotting, suggested working dilution: 1 to 4 ug/ml. It is recommended that thereagent be titrated for optimal performance for each application.

Purification: The antibody was purified by affinity chromatography.

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Storage: The antibody solution should be stored undiluted at 4 degrees C.

Restrictions: For Research Use only