Survivin (BIRC5) (pThr34) antibody

Antigen: Survivin (BIRC5)

Synonyms: Api4, TIAP, AAC-11, survivin40, bir5a, survivin, bir1-A, svv1, XBIR1, Xsvv1, birc5.1-A, xSurvivin, XSurvivin1, LOC398389, LOC398418, Su2, birc5.1-B, BIRC5, BIR1, Survivin, Survivin1, xSurvivin1, SIX, Su1, api4, svv2, birc5, epr-1, xSurvivin2

Epitope: pThr34

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunofluorescence (IF)

Catalog no.: ABIN314117

Additional Information

Alternative name: Survivin-Phosphorylated (Thr34)

Immunogen: Modified peptide

Format: Purified

Isotype: IgG  (Matching secondary antibodies)

Clone: Poly6326

Description: Survivin (also known as baculoviral IAP repeat-containing protein (BIRC5)) isa member of the IAP family containing a BIR domain. This protein has tworeported isoforms alpha and beta, with reported molecular weights of approximately16.5 kD and 18.6 kD, respectively. Survivin can form dimers and is distributedat the microtubules of the mitotic spindle. Survivin plays a possible role inneoplasia and is expressed in embryonic tissues and the majority of humancancers, but not in most normal adult tissues. Survivin may counteract defaultinduction of apoptosis in G2/M phase, and inhibits caspase-3 and caspase-7activation. Survivin is downregulated by p53 and stabilized byphosphorylation. Survivin is phosphorylated by cdc2. Survivin has beenshown to interact with tubulin and HBXIP. The Poly6326 antibody recognizesthe human survivin and has been shown to be useful for immunofuorescencemicroscopy.

Synonyms: Api4, TIAP, AAC-11, survivin40, bir5a, survivin, bir1-A, svv1, XBIR1, Xsvv1, birc5.1-A, xSurvivin, XSurvivin1, LOC398389, LOC398418, Su2, birc5.1-B, BIRC5, BIR1, Survivin, Survivin1, xSurvivin1, SIX, Su1, api4, svv2, birc5, epr-1, xSurvivin2

Application Details

Application Notes: Each lot of this antibody is quality control tested by immunofluorescencestaining. For immunofluorescence microscopy: Use a dilution range of1:100~1:400. It is recommended that the reagent be titrated for optimalperformance for each application.

Purification: The antibody was purified by antigen-affinity chromatography.

Buffer: This antibody is provided in phosphate-buffered solution, pH 7.2, containing0.09% sodium azide and 50% glycerol.

Storage: Upon receipt, store frozen at -20 degrees C.

Restrictions: For Research Use only