OGG1 antibody (8-Oxoguanine DNA Glycosylase) (HRP)

Details for Product anti-OGG1 Antibody No. ABIN314156, Supplier: Log in to see
Antigen
  • OGG1
  • zgc:158858
  • 8-oxoguanine-DNA glycosylase 1
  • ARABIDOPSIS 8-OXOGUANINE-DNA GLYCOSYLASE 1
  • ATOGG1
  • F8K7.14
  • F8K7_14
  • 19.m02329
  • DDBDRAFT_0184479
  • DDBDRAFT_0233024
  • DDB_0184479
  • DDB_0233024
  • ogg1
  • Tb04.1H19.930
  • HMMH
  • HOGG1
  • MUTM
  • OGH1
  • Mmh
  • 8-oxoguanine DNA glycosylase
  • 8-oxoguanine-DNA glycosylase 1
  • 8-OXOGUANINE DNA GLYCOSYLASE
  • 8-oxoguanine-DNA-glycosylase
  • 8-oxoguanine DNA-glycosylase
  • N-glycosylase/DNA lyase
  • 8-oxoguanine DNA-glycosylase 1
  • OGG1
  • ogg1
  • ECU08_0770
  • CAC2707
  • BBOV_I004290
  • Smp_074010.1
  • Tb927.4.2480
  • Ogg1
Alternatives
anti-Rat (Rattus) OGG1 antibody for ELISA
Reactivity
Human, Mouse (Murine), Primate, Rat (Rattus)
126
70
65
11
8
2
2
2
1
1
Host
Rabbit
83
44
20
Clonality
Polyclonal
Conjugate
This OGG1 antibody is conjugated to HRP
9
8
6
4
4
4
4
4
4
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Application
ELISA, Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
90
69
46
44
44
43
37
16
11
5
2
Options
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Immunogen A peptide derived from human Ogg1 (within amino acids 1-100). [UniProt# O15527]
Purification Immunogen affinity purified
Alternative Name OGG1 (OGG1 Antibody Abstract)
Background Gene Symbol: OGG1
Molecular Weight Theoretical MW: 39 kDa
Gene ID 4968
UniProt O15527
Pathways DNA Damage Repair
Application Notes Western Blot, ELISA, Immunohistochemistry, Immunohistochemistry-FrozenThis Ogg1 antibody is useful for Immunohistochemistry on frozen and paraffin-embedded sections, Immunoprecipitation Co-IP (PMID: 20956573), ELISA (PMID: 19506022) and Western Blot. In WB, it recognizes a band at ~39 kDa, representing Ogg1. In ICC/IF nuclear staining was observed in Hek293 cells. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Comment

The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.

Restrictions For Research Use only
Format Liquid
Buffer PBS
Buffer contains: No Preservative
Preservative Without preservative
Storage 4 °C
Storage Comment Store at 4°C in the dark.
Product cited in: Roseborough, Gao, Chen, Trush, Zhou, Williams, Wei: "The mitochondrial K-ATP channel opener, diazoxide, prevents ischemia-reperfusion injury in the rabbit spinal cord." in: The American journal of pathology, Vol. 168, Issue 5, pp. 1443-51, 2006 (PubMed).

Xydas, Kherani, Chang, Klotz, Hay, Mutrie, Moss, Gu, Schulman, Gao, Hu, Wu, Wei, Oz, Wang: "beta(2)-Adrenergic stimulation attenuates left ventricular remodeling, decreases apoptosis, and improves calcium homeostasis in a rodent model of ischemic cardiomyopathy." in: The Journal of pharmacology and experimental therapeutics, Vol. 317, Issue 2, pp. 553-61, 2006 (PubMed).

Rachek, Thornley, Grishko, LeDoux, Wilson: "Protection of INS-1 cells from free fatty acid-induced apoptosis by targeting hOGG1 to mitochondria." in: Diabetes, Vol. 55, Issue 4, pp. 1022-8, 2006 (PubMed).

Chen, Yu, Zhu, Lopez: "The p53 pathway promotes efficient mitochondrial DNA base excision repair in colorectal cancer cells." in: Cancer research, Vol. 66, Issue 7, pp. 3485-94, 2006 (PubMed).

Druzhyna, Musiyenko, Wilson, LeDoux: "Cytokines induce nitric oxide-mediated mtDNA damage and apoptosis in oligodendrocytes. Protective role of targeting 8-oxoguanine glycosylase to mitochondria." in: The Journal of biological chemistry, Vol. 280, Issue 22, pp. 21673-9, 2005 (PubMed).

Stuart, Hashiguchi, Wilson, Copeland, Souza-Pinto, Bohr: "DNA base excision repair activities and pathway function in mitochondrial and cellular lysates from cells lacking mitochondrial DNA." in: Nucleic acids research, Vol. 32, Issue 7, pp. 2181-92, 2004 (PubMed).

Hashiguchi, Stuart, de Souza-Pinto, Bohr: "The C-terminal alphaO helix of human Ogg1 is essential for 8-oxoguanine DNA glycosylase activity: the mitochondrial beta-Ogg1 lacks this domain and does not have glycosylase activity." in: Nucleic acids research, Vol. 32, Issue 18, pp. 5596-608, 2004 (PubMed).

Tuo, Chen, Zeng, Christiansen, Bohr: "Functional crosstalk between hOgg1 and the helicase domain of Cockayne syndrome group B protein." in: DNA repair, Vol. 1, Issue 11, pp. 913-27, 2003 (PubMed).

Tyrberg, Anachkov, Dib, Wang-Rodriguez, Yoon, Levine: "Islet expression of the DNA repair enzyme 8-oxoguanosine DNA glycosylase (Ogg1) in human type 2 diabetes." in: BMC endocrine disorders, Vol. 2, Issue 1, pp. 2, 2002 (PubMed).

Dobson, Grishko, LeDoux, Kelley, Wilson, Gillespie: "Enhanced mtDNA repair capacity protects pulmonary artery endothelial cells from oxidant-mediated death." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 283, Issue 1, pp. L205-10, 2002 (PubMed).

Rachek, Grishko, Musiyenko, Kelley, LeDoux, Wilson: "Conditional targeting of the DNA repair enzyme hOGG1 into mitochondria." in: The Journal of biological chemistry, Vol. 277, Issue 47, pp. 44932-7, 2002 (PubMed).

Lin, Cao, Yu, Cui, Hamilton, Liu: "Up-regulation of base excision repair activity for 8-hydroxy-2'-deoxyguanosine in the mouse brain after forebrain ischemia-reperfusion." in: Journal of neurochemistry, Vol. 74, Issue 3, pp. 1098-105, 2000 (PubMed).

Background publications Mambo, Nyaga, Bohr, Evans: "Defective repair of 8-hydroxyguanine in mitochondria of MCF-7 and MDA-MB-468 human breast cancer cell lines." in: Cancer research, Vol. 62, Issue 5, pp. 1349-55, 2002 (PubMed).

Potts, Watkin, Hart: "Cadmium exposure down-regulates 8-oxoguanine DNA glycosylase expression in rat lung and alveolar epithelial cells." in: Toxicology, Vol. 184, Issue 2-3, pp. 189-202, 2002 (PubMed).

Fan, Liu, Huang, Barnes, Swalsky, Bakker, Woods, Finkelstein: "Frequent allelic imbalance and loss of protein expression of the DNA repair gene hOGG1 in head and neck squamous cell carcinoma." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 81, Issue 10, pp. 1429-38, 2001 (PubMed).