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Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 11 (SLC7A11) (AA 1-50), (N-Term) antibody (HRP)

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Synonyms SLC7A11, DKFZp468E122, CCBR1, xCT, 9930009M05Rik, AI451155, sut
N-Term, AA 1-50
(17), (16), (13), (2), (1), (1)
Human, Mouse (Murine)
(52), (18), (18), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1)
(39), (19)
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(31), (18), (16), (11), (8), (1)
Pubmed 1 reference available
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Quantity 0.1 mL
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Immunogen A synthetic peptide made to an N-terminal region of the human xCT protein (between residues 1-50)
Purification affinity purified
Alternative Name XCT / SLC7A11 (SLC7A11 Antibody Abstract)
Background Mammalian amino acid transport systems consist of a large variety of transporters. Theamino acid transporter, cystine/glutamic acid transporter xCT, for system xc has beenproposed to be responsible for the cystine transport through the plasma membrane.System xc mediates an amino acid exchange and prefers cystine and glutamate as itssubstrates. The transporter designated as xCT requires 4F2 heavy chain (4F2hc:CD98)for its functional expression, and belongs to the family of amino acid transporters thatassociates with the type II membrane glycoproteins such as 4F2hc. In brain, it has beenproposed that system xc is up-regulated in glial cells upon oxidative stress and plays anessential roles to protect neurons against oxidative stress. Recent studies haveimplicated xCT as a gateway that Kaposi's sarcoma herpesvirus (KSHV) uses to entercells. Alternate Names: anti-Cysteine/glutamate transporter antibody, anti-Amino acid transport system xc-xCTantibody, anti-Calcium channel blocker resistance protein CCBR1 antibody, anti-SoluteCarrier Family 7 antibody, anti-Member 11 (SCL7a11) antibody, anti-SLC7a11 antibody.
Gene Symbol: SLC7A11
Gene ID 23657
UniProt Q9UPY5
Application Notes This xCT antibody is useful for Western blot, Immunocytochemistry/Immunofluorescence, Immunohistochemistry and Flow (PMID 20028852). Immunoprecipitation is not recommended. In Western blot this antibody recognizes a band at ~55 kDa, and in ICC/IF membrane staining was observed in HepG2 cells. Permeablization is recommended prior to performing Flow analysis.
Recommended dilutions: Immunohistochemistry-Paraffin 5 µg/mL, Western Blot 1:1000, Immunohistochemistry 5 µg/mL
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS
Preservative Without preservative
Storage 4 °C
Storage Comment 4 °C in the dark
Product cited in: Liu, Blower, Pham et al.: "Cystine-glutamate transporter SLC7A11 mediates resistance to geldanamycin but not to 17-(allylamino)-17-demethoxygeldanamycin." in: Molecular pharmacology, Vol. 72, Issue 6, pp. 1637-46, 2007 (PubMed).

Catalog No. ABIN314186
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