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Details for Product No. ABIN314186

Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 11 (SLC7A11) antibody

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Synonyms xCT, CCBR1, sut, AI451155, 9930009M05Rik, SLC7A11, DKFZp468E122
»Alternatives Human, Mouse (Murine)
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN314186
Quantity 0.1 mL
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Immunogen A synthetic peptide made to a region within the N-terminus of the human XCT proteinsequence (between residues 1-50).
Specificity This antibody is specific for XCT. Species Reactivity: This antibody reacts with the human and mouse proteins. Other species have not beentested.
Alternative Name XCT / SLC7A11
Background Mammalian amino acid transport systems consist of a large variety of transporters. Theamino acid transporter, cystine/glutamic acid transporter xCT, for system xc has beenproposed to be responsible for the cystine transport through the plasma membrane.System xc mediates an amino acid exchange and prefers cystine and glutamate as itssubstrates. The transporter designated as xCT requires 4F2 heavy chain (4F2hc:CD98)for its functional expression, and belongs to the family of amino acid transporters thatassociates with the type II membrane glycoproteins such as 4F2hc. In brain, it has beenproposed that system xc is up-regulated in glial cells upon oxidative stress and plays anessential roles to protect neurons against oxidative stress. Recent studies haveimplicated xCT as a gateway that Kaposi's sarcoma herpesvirus (KSHV) uses to entercells. Alternate Names: anti-Cysteine/glutamate transporter antibody, anti-Amino acid transport system xc-xCTantibody, anti-Calcium channel blocker resistance protein CCBR1 antibody, anti-SoluteCarrier Family 7 antibody, anti-Member 11 (SCL7a11) antibody, anti-SLC7a11 antibody.
Gene ID 23657
UniProt Q9UPY5
Application Notes Suggested working dilutions: immunohistochemistry (FFPE),Western Blot 1:1000. Positive Controls: stomach tissue lysate
Restrictions For Research Use only
Concentration 1.0 mg/ml
Buffer Tris-glycine with 150mM NaCl. Preservative: 0.05% sodium azide.
Preservative Sodium azide
Storage 4 °C
Liu, Blower, Pham et al.: "Cystine-glutamate transporter SLC7A11 mediates resistance to geldanamycin but not to 17-(allylamino)-17-demethoxygeldanamycin." in: Molecular pharmacology, Vol. 72, Issue 6, pp. 1637-46, 2007 (PubMed).

Alternatives for antigen "Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 11 (SLC7A11)", type "Antibodies"
Hosts (50), (7)
Reactivities (47), (26), (19), (15), (12), (11), (1)
Applications (38), (20), (9), (7), (6), (5), (5), (3), (2), (1)
Conjugates (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (20), (9), (5), (1), (1)