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PR Domain Containing 1, with ZNF Domain (PRDM1) (AA 199-409) antibody (Biotin)

Details for Product No. ABIN314189, Supplier: Log in to see
Antigen
  • GB11750
  • CG5249
  • Dmel\\CG5249
  • blimp-1
  • dBlimp-1
  • dBlimp1
  • Blimp-1
  • Blimp1
  • nrd
  • prdm1
  • ubo
  • wu:fb99c12
  • zgc:91885
  • MGC52536
  • PRDM1
  • blimp1
  • xblimp1
  • prdi-bf1
  • BLIMP1
  • PRDI-BF1
  • ZNFPR1A1
  • PR domain containing 1, with ZNF domain
  • Blimp-1 protein
  • CG5249 gene product from transcript CG5249-RB
  • blimp-1
  • PR domain containing 1a, with ZNF domain
  • B lymphocyte induced maturation protein 1
  • PRDM1
  • LOC100338324
  • Blimp-1
  • CpipJ_CPIJ007425
  • prdm1a
  • prdm1
  • Prdm1
Epitope
AA 199-409
32
20
18
12
9
9
8
7
7
7
6
5
5
5
5
3
3
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Pig (Porcine)
174
77
42
26
15
11
4
3
3
3
2
2
2
Host
Mouse
87
64
32
3
Clonality (Clone)
Monoclonal ()
Conjugate
Biotin
9
9
7
5
5
4
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
169
125
33
30
29
24
21
15
11
7
3
2
2
1
1
1
1
1
Options
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Immunogen A fragment of mouse Blimp-1 corresponding to residues 199-409. [UniProt# Q60636]
Clone 3H2-E8
Isotype IgG1
Purification Protein G purified
Alternative Name BLIMP1/PRDM1 (PRDM1 Antibody Abstract)
Background Gene Symbol: PRDM1
Gene ID 639
UniProt Q60636
Pathways Regulation of Muscle Cell Differentiation
Application Notes Western Blot, ELISA, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-FrozenThis Blimp-1 (3H2-E8) antibody is useful for ELISA, Immunocytochemistry/Immunofluorescence, Western Blot, Immunohistochemistry on paraffin-embedded sections and Flow Cytometry. Immunohistochemistry-Frozen was reported in scientific literature. By WB, this antibody recognizes a band at ~98 kDa and may recognize one at ~80 kDa (the beta form). Antigen retrieval is recommended (EDTA buffer, microwave) prior to IHC on paraffin tissues. This antibody demonstrates nuclear staining. This antibody does not immunoprecipitate. For IHC and ICC/IF a dilution of 1:200 is recommended with tyramide amplification.
Comment

The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.

Restrictions For Research Use only
Format Liquid
Buffer PBS
Buffer contains: 0.05 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 4°C in the dark.
Supplier Images
Flow Cytometry (FACS) image for anti-PR Domain Containing 1, with ZNF Domain (PRDM1) (AA 199-409) antibody (Biotin) (ABIN314189) anti-PR Domain Containing 1, with ZNF Domain (PRDM1) (AA 199-409) antibody (Biotin)
Flow Cytometry (FACS) image for anti-PR Domain Containing 1, with ZNF Domain (PRDM1) (AA 199-409) antibody (Biotin) (ABIN314189) anti-PR Domain Containing 1, with ZNF Domain (PRDM1) (AA 199-409) antibody (Biotin) (Image 2)
Flow Cytometry (FACS) image for anti-PR Domain Containing 1, with ZNF Domain (PRDM1) (AA 199-409) antibody (Biotin) (ABIN314189) anti-PR Domain Containing 1, with ZNF Domain (PRDM1) (AA 199-409) antibody (Biotin) (Image 3)
Flow Cytometry (FACS) image for anti-PR Domain Containing 1, with ZNF Domain (PRDM1) (AA 199-409) antibody (Biotin) (ABIN314189) Flow Cytometry: Blimp-1 Antibody (3H2-E8) [Biotin] [ABIN314189B] - Blimp-1 in mouse s...
Product cited in: John, Clements, Russell, Garrett-Sinha: "Ets-1 regulates plasma cell differentiation by interfering with the activity of the transcription factor Blimp-1." in: The Journal of biological chemistry, Vol. 283, Issue 2, pp. 951-62, 2008 (PubMed).

Liu, Leboeuf, Shi, Li, Wang, Shen, Garcia, Shen, Chen, Janin, Chen, Zhao: "Rituximab plus CHOP (R-CHOP) overcomes PRDM1-associated resistance to chemotherapy in patients with diffuse large B-cell lymphoma." in: Blood, Vol. 110, Issue 1, pp. 339-44, 2007 (PubMed).

Robertson, Charatsi, Joyner, Koonce, Morgan, Islam, Paterson, Lejsek, Arnold, Kallies, Nutt, Bikoff: "Blimp1 regulates development of the posterior forelimb, caudal pharyngeal arches, heart and sensory vibrissae in mice." in: Development (Cambridge, England), Vol. 134, Issue 24, pp. 4335-45, 2007 (PubMed).

Severa, Coccia, Fitzgerald: "Toll-like receptor-dependent and -independent viperin gene expression and counter-regulation by PRDI-binding factor-1/BLIMP1." in: The Journal of biological chemistry, Vol. 281, Issue 36, pp. 26188-95, 2006 (PubMed).

Gong, Malek: "Cytokine-dependent Blimp-1 expression in activated T cells inhibits IL-2 production." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 1, pp. 242-52, 2006 (PubMed).

Ohinata, Payer, OCarroll, Ancelin, Ono, Sano, Barton, Obukhanych, Nussenzweig, Tarakhovsky, Saitou, Surani: "Blimp1 is a critical determinant of the germ cell lineage in mice." in: Nature, Vol. 436, Issue 7048, pp. 207-13, 2005 (PubMed).

Cattoretti, Angelin-Duclos, Shaknovich, Zhou, Wang, Alobeid: "PRDM1/Blimp-1 is expressed in human B-lymphocytes committed to the plasma cell lineage." in: The Journal of pathology, Vol. 206, Issue 1, pp. 76-86, 2005 (PubMed).

Lin, Angelin-Duclos, Kuo, Calame: "Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells." in: Molecular and cellular biology, Vol. 22, Issue 13, pp. 4771-80, 2002 (PubMed).

Angelin-Duclos, Cattoretti, Lin, Calame: "Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 10, pp. 5462-71, 2000 (PubMed).

Background publications Chang, Cattoretti, Calame: "The dynamic expression pattern of B lymphocyte induced maturation protein-1 (Blimp-1) during mouse embryonic development." in: Mechanisms of development, Vol. 117, Issue 1-2, pp. 305-9, 2002 (PubMed).

Lin, Wong, Calame: "Repression of c-myc transcription by Blimp-1, an inducer of terminal B cell differentiation." in: Science (New York, N.Y.), Vol. 276, Issue 5312, pp. 596-9, 1997 (PubMed).