TAR DNA Binding Protein (TARDBP) (AA 1-260) antibody

Details for Product No. ABIN316132
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Antigen
Epitope
AA 1-260
(23), (22), (15), (13), (8), (7), (7), (4), (3), (3), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(124), (56), (48), (23), (16), (8), (7), (6), (5), (3), (1), (1)
Host
Mouse
(95), (30), (5), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(114), (48), (35), (28), (27), (21), (10), (9), (5), (4), (2), (2), (1), (1)
Pubmed 1 reference available
Quantity 0.1 mL
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN316132
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Immunogen Recombinant human TARDBP (1-260aa) purified from E. coli
Clone K1B8
Isotype IgG1
Purification Protein G purified
Alternative Name TARDBP
Background TAR DNA binding protein (TARDBP), also known as TDP-43, is a cellular protein.TARDBP was identified as the disease accumulating protein in patients withfrontotemporal lobar degeneration (FTLD) with ubiquitin inclusions (FTLD-U) and inamyotrophic lateral sclerosis (ALS). TARDBP functions as a DNA-binding protein andspecifically binds to the TAR DNA sequence motifs of HIV. Via this association with TARmotifs, TARDBP acts as a transcriptional repressor and inhibits HIV-1 transcription. Inaddition, this protein regulates alternate splicing of the cystic fibrosis transmembranereceptor (CFTR) gene.
Gene Symbol: TARDBP
Gene ID 23435
Research Area Chromatin and Nuclear Signaling, Transcription Factors, DNA/RNA, Hormones, Cytokines
Application Notes The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. This antibody is also useful for Immunohistochemistry-Paraffin at a dilution of 1:100-1:300.
Recommended dilutions: Western Blot 1:1000, ELISA, Immunohistochemistry-Paraffin 1:50, Immunohistochemistry
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer Phosphate buffered Saline (pH 7.4), Sodium Azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
General Geser, Martinez-Lage, Robinson et al.: "Clinical and pathological continuum of multisystem TDP-43 proteinopathies." in: Archives of neurology, Vol. 66, Issue 2, pp. 180-9, 2009 (PubMed).

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