TAR DNA Binding Protein (TARDBP) antibody

Details for Product No. ABIN316132
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Antigen
Synonyms ALS10, TDP-43, Tdp43, C85084, 1190002A23Rik, wu:fb77f02, wu:fc52g10, TARDBP, TDP43, DKFZp459I2127, tardbp
Reactivity
Human
(110), (64), (50), (29), (16), (14), (14), (12), (5), (3), (1)
Host
Mouse
(85), (27), (5), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB), ELISA
(98), (47), (23), (21), (19), (18), (10), (3), (2), (2), (1)
Pubmed 1 reference available
Catalog no. ABIN316132
Quantity 0.1 mL
Price
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Immunogen Recombinant human TARDBP (1-260aa) purified from E. coli.
Clone K1B8
Isotype IgG1
Specificity Anti-human TARDBP mAb, clone k1B8, is derived from hybridization of mouse FOmyeloma cells with spleen cells from BALB/c mice immunized with a recombinanthuman TARDBP protein. Species Reactivity: This antibody is reactive against Human.
Cross-Reactivity Human
Purification Purified
Alternative Name TARDBP
Background TAR DNA binding protein (TARDBP), also known as TDP-43, is a cellular protein.TARDBP was identified as the disease accumulating protein in patients withfrontotemporal lobar degeneration (FTLD) with ubiquitin inclusions (FTLD-U) and inamyotrophic lateral sclerosis (ALS). TARDBP functions as a DNA-binding protein andspecifically binds to the TAR DNA sequence motifs of HIV. Via this association with TARmotifs, TARDBP acts as a transcriptional repressor and inhibits HIV-1 transcription. Inaddition, this protein regulates alternate splicing of the cystic fibrosis transmembranereceptor (CFTR) gene.
Research Area Chromatin and Nuclear Signaling, Transcription Factors, DNA/RNA, Hormones, Cytokines
Application Notes Western Blot 1:1000-1:2000
Restrictions For Research Use only
Format Liquid
Concentration 1mg/ml
Buffer Phosphate-Buffered Saline (pH 7.4). Preservative: 0.1% Sodium Azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
General Geser, Martinez-Lage, Robinson et al.: "Clinical and pathological continuum of multisystem TDP-43 proteinopathies." in: Archives of neurology, Vol. 66, Issue 2, pp. 180-9, 2009 (PubMed).

Hosts (85), (27), (5), (1)
Reactivities (110), (64), (50), (29), (16), (14), (14), (12), (5), (3), (1)
Applications (98), (47), (23), (21), (19), (18), (10), (3), (2), (2), (1)
Conjugates (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (17), (15), (9), (7), (7), (7), (3), (2), (2), (2), (2), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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