Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin (SIGLEC1) antibody (FITC)

Details for Product No. ABIN316948
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Antigen
Synonyms Cd169, Siglec-1, Sn, CD169, SIGLEC-1, SN, dJ1009E24.1, SA, SIGLEC1, p210, pSn
Reactivity
Human
(33), (26), (8), (6)
Host
Mouse
(26), (22), (18), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
FITC
(13), (3), (3)
Application
Flow Cytometry (FACS)
(46), (34), (17), (14), (13), (11), (10), (5), (3), (2), (1)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN316948
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Immunogen Human Rhinovirus (HRV14) treated monocyte-derived dendritic cells.
Clone 30-06-39
Isotype IgG1
Specificity This antibody specifically recognises CD169, otherwise known as Sialoadhesin (Sn). Clone 7-239 completely inhibits erythrocyte rosetting around Sn+ transductants. AM05587LE-N is recommneded for use in Functional Studies.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Characteristics Synonyms: Sialoadhesin, Siglec-1, Sialic acid-binding Ig-like lectin 1
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Alternative Name CD169 / SIGLEC1
Background CD169 is a type I transmembrane glycoprotein and prototypic member of the Siglec (sialic acid binding Ig-like lectin) family, designated Siglec-1. CD169 is a macrophage-restricted interaction molecule which binds to sialylated ligands on haematopoietic cells, including neutrophils, NK cells, monocytes, a subset of CD8+ T cells and B cells, through recognition of sialic acid in the alpha-2,3- glycosidic linkage. CD169 is highly expressed by dendritic cells and on stromal macrophages in the spleen, bone marrow and lymph nodes and to a lesser extent in liver, lungs and gut, and studies have shown high expression of CD169 on macrophages in the inflammatory conditions rheumatoid arthritis and atherosclerosis.Synonyms: Sialic acid-binding Ig-like lectin 1, Sialoadhesin, Siglec-1
Gene ID 6614
UniProt Q9BZZ2
Application Notes Flow Cytometry: Use 10 μL of neat-1/10 diluted antibody to label 10^6 cells in 100 μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light.
Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Hartnell, Steel, Turley et al.: "Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations." in: Blood, Vol. 97, Issue 1, pp. 288-96, 2001 (PubMed).

Kirchberger, Majdic, Steinberger et al.: "Human rhinoviruses inhibit the accessory function of dendritic cells by inducing sialoadhesin and B7-H1 expression." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 2, pp. 1145-52, 2005 (PubMed).

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