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PLVAP antibody

PLVAP Reactivity: Mouse FACS, IHC (fro) Host: Rat Monoclonal MECA-32 unconjugated
Catalog No. ABIN316988
  • Target See all PLVAP Antibodies
    PLVAP (Plasmalemma Vesicle Associated Protein (PLVAP))
    Reactivity
    • 28
    • 7
    • 1
    Mouse
    Host
    • 21
    • 7
    • 5
    Rat
    Clonality
    • 22
    • 10
    Monoclonal
    Conjugate
    • 19
    • 5
    • 3
    • 2
    • 2
    • 2
    This PLVAP antibody is un-conjugated
    Application
    • 30
    • 22
    • 16
    • 9
    • 7
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Characteristics
    Synonyms: Plasmalemma vesicle protein 1, PV1, PV-1, MECA-32 antigen, FELS, Endothelial cell marker,Endothelial cell surface marker, Endothelial Cell Antigen, Plasmalemma vesicle-associatedprotein, Fenestrated endothelial-linked structure protein
    Purification
    Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
    Clone
    MECA-32
    Isotype
    IgG2a
    Top Product
    Discover our top product PLVAP Primary Antibody
  • Application Notes
    Flow Cytometry. Immunohistochemistry on frozen sections: 1/25 - 1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0mg/mL
    Buffer
    Phosphate buffered saline pH 7.4 containing 0.09 % Sodium Azide (NaN3)
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
    Shelf life: one year from despatch. Caution: (A full Health and Safety assessment is available upon request) This product containsSodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by
    Expiry Date
    12 months
  • Target
    PLVAP (Plasmalemma Vesicle Associated Protein (PLVAP))
    Alternative Name
    PLVAP (PLVAP Products)
    Synonyms
    MECA32 antibody, Pv1 antibody, FELS antibody, PV-1 antibody, PV1 antibody, gp68 antibody, plasmalemma vesicle associated protein antibody, Plvap antibody, PLVAP antibody
    Background
    PLVAP is a 60kD protein which is otherwise known as MECA-32 and PV-1. PLVAP is a transmembrane homodimer which is associated with endothelial cell caveolae and fenestrae. In adult and embryonic mice, PLVAP is primarily expressed on endothelial tissues but shows restricted distribution in the skeletal, cardiac and brain tissues. In embryonic mice, PLVAP expression, on the vasculature associated with blood brain barrier has been reported to be developmentally regulated. In humans, PLVAP is selectively up-regulated in a variety of high-grade brain tumors, including glioblastoma and metastatic carcinoma, as well as other cerebral disorders associated with blood-brain barrier disruption, such as acute ischemia. PLVAP represents a novel marker of brain tumour angiogenesis and integrity of the blood-brain barrier and is a potential therapeutic target.Synonyms: Endothelial Cell Antigen, Endothelial cell marker, Endothelial cell surface marker, FELS, Fenestrated endothelial-linked structure protein, MECA-32 antigen, PV-1, PV1, Plasmalemma vesicle protein 1, Plasmalemma vesicle-associated protein
    UniProt
    Q9BX97
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