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CD274 Molecule (CD274) antibody (FITC)

Details for Product No. ABIN317020
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Antigen
Synonyms A530045L16Rik, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1, B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1, RGD1566211
Reactivity
Mouse (Murine)
(103), (95), (50), (20), (20)
Host
Rat
(78), (39), (37), (7)
Clonality (Clone)
Monoclonal ()
Conjugate
FITC
(18), (11), (10), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS)
(88), (67), (37), (28), (24), (20), (15), (7), (5), (4), (2), (2), (1)
Pubmed 2 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN317020
434.50 $
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Immunogen Mouse CD274 - transfected L5178Y cells
Clone MIH6
Isotype IgG2a
Characteristics Synonyms: PD-L1, PDCD1 ligand 1, B7H1, B7 homolog 1, PDCD1L1, PDCD1LG1, Programmed cell death 1ligand 1, Programmed death ligand 1
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Alternative Name CD274 / PDL1
Background CD274 is a cell surface glycoprotein which is a member of the B7 family of co-stimulatorymolecules. CD274 is expressed constitutively on macrophages and dendritic cells, and isinduced on activated T-cells, B-cells, endothelial cells and epithelial cells in response toInterferons alpha, beta and gamma. CD274 is reported to possess dual functions, inhibition of activated effector T cells andco-stimulation of naive T cells. CD274 inhibits proliferation of activated T cells via ligationto the co-inhibitory molecule CD279 (programmed death-1, PD-1) leading to the secretion ofthe regulatory cytokine interleukin-10. CD274 has also been shown to costimulate early Tcell priming and differentiation. Deregulated CD274 function has been reported in chronicviral and intracellular bacterial infection, as well as in many autoimmune diseases andcancers.
UniProt Q9EP73
Application Notes Flow Cytometry: Use 10 µl of neat antibody to label 1x10e6 cells in 100 µl. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.1 mg/mL
Buffer Phosphate buffered saline pH 7.4 containing 0.09% Sodium Azide as preservative and 1% BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-CD274 Molecule (CD274) antibody (FITC) anti-CD274 Molecule (CD274) antibody (FITC)
Background publications Yamazaki, Akiba, Iwai et al.: "Expression of programmed death 1 ligands by murine T cells and APC." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 10, pp. 5538-45, 2002 (PubMed).

Kanai, Totsuka, Uraushihara et al.: "Blockade of B7-H1 suppresses the development of chronic intestinal inflammation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 8, pp. 4156-63, 2003 (PubMed).

Validation Images
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