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PD-L1 antibody (CD274 Molecule) (FITC)

Details for Product anti-CD274 Antibody No. ABIN317020, Supplier: Login to see New
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Synonyms A530045L16Rik, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1, B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1, RGD1566211
Mouse (Murine)
(194), (93), (21), (1), (1)
(96), (90), (59), (20), (2)
Clonality (Clone)
Monoclonal ()
This PD-L1 antibody is conjugated to FITC
(23), (19), (18), (13), (6), (3), (3), (3), (2), (2), (2), (1), (1)
Flow Cytometry (FACS)
(126), (117), (81), (44), (16), (16), (15), (8), (6), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Pubmed 2 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Mouse CD274 - transfected L5178Y cells
Clone MIH6
Isotype IgG2a
Specificity This antibody detects CD274, also known as B7-H1 and PD-1L.
Cross-Reactivity (Details) Species reactivity (tested):Mouse.
Characteristics Synonyms: PD-L1, PDCD1 ligand 1, B7H1, B7 homolog 1, PDCD1L1, PDCD1LG1, Programmed cell death 1ligand 1, Programmed death ligand 1
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Alternative Name CD274 / PDL1 (CD274 Antibody Abstract)
Background CD274 is a cell surface glycoprotein which is a member of the B7 family of co-stimulatory molecules. CD274 is expressed constitutively on macrophages and dendritic cells, and is induced on activated T-cells, B-cells, endothelial cells and epithelial cells in response to Interferons alpha, beta and gamma. CD274 is reported to possess dual functions, inhibition of activated effector T cells and co-stimulation of naive T cells. CD274 inhibits proliferation of activated T cells via ligation to the co-inhibitory molecule CD279 (programmed death-1, PD-1) leading to the secretion of the regulatory cytokine interleukin-10. CD274 has also been shown to costimulate early T cell priming and differentiation. Deregulated CD274 function has been reported in chronic viral and intracellular bacterial infection, as well as in many autoimmune diseases and cancers.Synonyms: B7 homolog 1, B7H1, PD-L1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, Programmed cell death 1 ligand 1, Programmed death ligand 1
Gene ID 60533
UniProt Q9EP73
Application Notes Flow Cytometry: Use 10 μL of neat antibody to label 1x10^6 cells in 100 μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer Phosphate buffered saline pH 7.4 containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
Flow Cytometry (FACS) image for anti-PD-L1 antibody (CD274 Molecule)  (FITC) (ABIN317020) anti-CD274 Molecule (CD274) antibody (FITC)
Background publications Kanai, Totsuka, Uraushihara et al.: "Blockade of B7-H1 suppresses the development of chronic intestinal inflammation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 8, pp. 4156-63, 2003 (PubMed).

Yamazaki, Akiba, Iwai et al.: "Expression of programmed death 1 ligands by murine T cells and APC." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 10, pp. 5538-45, 2002 (PubMed).

Catalog No. ABIN317020
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