CD11b antibody (Integrin alpha M)

Details for Product anti-ITGAM Antibody No. ABIN317369, Supplier: Log in to see
Antigen
  • CD11b/CD18
  • CR3
  • CR3A
  • Cd11b
  • F730045J24Rik
  • Ly-40
  • MAC1
  • Mac-1
  • Mac-1a
  • CD11B
  • MAC-1
  • MAC1A
  • MO1A
  • SLEB6
  • C3bi
  • integrin, alpha M (complement component 3 receptor 3 subunit)
  • integrin alpha M
  • integrin, alpha M
  • ITGAM
  • Itgam
Alternatives
anti-Human CD11b antibody for Immunoprecipitation
Reactivity
Cow (Bovine), Dog (Canine), Cat (Feline), Goat, Mustelid, Pig (Porcine)
733
515
192
79
31
18
17
15
13
10
10
9
7
7
4
4
4
3
3
2
Host
Mouse
532
410
168
17
6
2
Clonality (Clone)
Monoclonal ()
Conjugate
This CD11b antibody is un-conjugated
150
128
94
56
24
24
20
17
15
14
14
13
13
13
11
11
11
10
9
7
7
6
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6
6
6
4
4
4
4
4
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
Application
Functional Studies (Func), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP)
930
237
235
172
172
138
100
98
97
67
25
21
21
18
14
8
5
5
4
3
3
1
1
1
1
1
1
1
1
1
Options
Supplier
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Supplier Product No.
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Clone CA16-3E10
Isotype IgG1
Specificity This antibody recognises the Canine CD11b cell surface antigen, a member of the alpha integrin family. Canine CD11b is expressed by granulocytes, monocytes and some macrophages.
Characteristics Synonyms: Integrin alpha-M, CR3A, MAC-1, MAC1, CR-3 alpha chain, Cell surface glycoprotein MAC-1subunit alpha, Leukocyte adhesion receptor MO1, Neutrophil adherence receptor, CD11antigen-like family member B
Purification Supernatant
Alternative Name CD11b (ITGAM Antibody Abstract)
Background CD11b is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement coated particles. It is identical to CR3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the RGD peptide in C3b. CD11b is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. The Mac1 CD11b antigen is present on macrophages, granulocytes, natural killer cells, blood monocytes. CD11b is expressed on 8 % spleen cells, 44 % bone marrow cells and less than 1 % of thymocytes and is commonly used as a microglial marker in nervous tissue.Synonyms: CD11 antigen-like family member B, CR-3 alpha chain, CR3A, Cell surface glycoprotein MAC-1 subunit alpha, ITGAM, Integrin alpha-M, Leukocyte adhesion receptor MO1, MAC1, Neutrophil adherence receptor
Gene ID 443217
UniProt A2TJJ2
Research Area Stem Cells, Hematopoietic Progenitors, Hematopoietic Stem Cells, Glia marker, CD Antigens, Surface Receptors of Immune Cells
Pathways Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation
Application Notes Immunohistochemistry on Frozen Sections. Immunoprecipitation. Flow Cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer Phosphate buffered saline pH 7.4 containing 0.09 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Brodersen, Bijlsma, Gori, Jensen, Chen, Dominguez, Haverson, Moore, Saalmüller, Sachs, Slierendrecht, Stokes, Vainio, Zuckermann, Aasted: "Analysis of the immunological cross reactivities of 213 well characterized monoclonal antibodies with specificities against various leucocyte surface antigens of human and 11 animal species." in: Veterinary immunology and immunopathology, Vol. 64, Issue 1, pp. 1-13, 1998 (PubMed).

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