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CSF1R antibody

CSF1R Reactivity: Mouse, Rat FACS, Func Host: Rat Monoclonal 604B5 2E11 unconjugated
Catalog No. ABIN317381
  • Target See all CSF1R Antibodies
    CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))
    Reactivity
    • 192
    • 135
    • 97
    • 17
    • 8
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Mouse, Rat
    Host
    • 224
    • 20
    • 9
    • 3
    • 2
    Rat
    Clonality
    • 226
    • 31
    • 1
    Monoclonal
    Conjugate
    • 93
    • 27
    • 15
    • 14
    • 13
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 5
    • 5
    • 5
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CSF1R antibody is un-conjugated
    Application
    • 174
    • 106
    • 81
    • 67
    • 50
    • 26
    • 24
    • 20
    • 12
    • 6
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Functional Studies (Func)
    Specificity
    This antibody recognizes the Murine CD115 cell surface antigen, also known as the M-CSF receptor and as c-fms. This antibody has been shown to inhibit in vitro colony formation in response to M-CSF in both rats and mice.
    Characteristics
    Synonyms: CSF-1-R, Fms proto-oncogene, c-fms, CSF1R, FMS, Macrophage colony-stimulating factor 1receptor
    Purification
    Purified IgG prepared by ion exchange chromatography
    Immunogen
    RAW 264 cells. Spleen cells from immunised Sprague Dawley rats were fused with cells of the P3-653myeloma cell line.
    Clone
    604B5 2E11
    Isotype
    IgG1
    Top Product
    Discover our top product CSF1R Primary Antibody
  • Application Notes
    Functional Assays. Flow Cytometry: Use 10 μL of 1/10-1/100 diluted antibody to label 10^6 cells in 100 μL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS, pH 7.4, None, None
    Preservative
    Without preservative
    Storage
    -20 °C
    Storage Comment
    Store the antibody undiluted at -20 °C. Avoid repeated freezing and thawing.
    Shelf life: one year from despatch.
    Expiry Date
    12 months
  • Target
    CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))
    Alternative Name
    CD115 (CSF1R Products)
    Synonyms
    AI323359 antibody, CD115 antibody, CSF-1R antibody, Csfmr antibody, Fim-2 antibody, Fms antibody, M-CSF-R antibody, M-CSFR antibody, C-FMS antibody, CSFR antibody, FIM2 antibody, FMS antibody, HDLS antibody, PDGFRB antibody, MGC89146 antibody, CSF-1-R antibody, c-fms antibody, mrfms antibody, CSF1 antibody, M-CSF antibody, csf1r antibody, fms antibody, panther antibody, colony stimulating factor 1 receptor antibody, macrophage colony-stimulating factor receptor antibody, colony stimulating factor 1 receptor, a antibody, Csf1r antibody, CSF1R antibody, m-csfr antibody, csf1r antibody, csf1ra antibody
    Background
    This protein tyrosine kinase transmembrane receptor is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a member of the CSF1/PDGF receptor family of tyrosine protein kinases and contains 5 immunoglobulin like C2 type domains. CD115 is expressed by cells of the monocytic lineage and by progenitor cells. Mutations in this gene have been associated with a predisposition to myeloid malignancy.Synonyms: CSF-1-R, CSF1R, FMS, Fms proto-oncogene, Macrophage colony-stimulating factor 1 receptor, c-fms
    Gene ID
    12978
    UniProt
    P09581
    Pathways
    RTK Signaling, Inositol Metabolic Process, Cell-Cell Junction Organization
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