Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR) antibody (Biotin)

Antigen: Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR)

Synonyms: CD18, TNFCR, D12S370, TNFR-RP, TNFRSF3, TNFR2-RP, LT-BETA-R, TNF-R-III

Clonality: Monoclonal (5G11b)

Host: Rat

Reactivity: Mouse (Murine)

Conjugate: Biotin

Application: Flow Cytometry (FACS)

Catalog no.: ABIN317395

Additional Information

Characteristics: Synonyms: Tumor necrosis factor receptor 3, TNF-R3, Tumor necrosis factor C receptor, TNFCR,TNFRSF3, D12S370, Lymphotoxin-beta receptor, Tumor necrosis factor receptor superfamilymember 3, Tumor necrosis factor receptor type III, Tumor necrosis factor receptor 2-relatedprotein

Alternative name: LTBR / TNFR3

Swiss-Prot: P50284

Immunogen: Recombinant extracellular domain of LT beta R

Cross-Reactivity: Mouse (Murine)

Isotype: IgG2a

Clone: 5G11b

Description: The protein encoded by this gene is a member of the tumor necrosis factor (TNF) family ofreceptors. It is expressed on the surface of most cell types, including cells of epithelial andmyeloid lineages, but not on T and B lymphocytes. The protein specifically binds thelymphotoxin membrane form (a complex of lymphotoxin alpha and lymphtoxin beta). Theencoded protein and its ligand play a role in the development and organization oflymphoid tissue and tranformed cells. Activation of the encoded protein can triggerapoptosis.

Specificity: This antibody recognises lymphotoxin-beta receptor (LT beta R), a member of the tumournecrosis factor family. LT beta R is primarily expressed on stromal cells and fibroblasts andat lower levels on myeloid cell lines. Clone 5G11b specifically recognises surface expressedLT beta R. The clone is reported to be agonistic with respect to NF KappaB activation, MIP-2induction and IL-6 release (2). Species: Mouse. Others not tested. Add. Information: The Fc region of monoclonal antibodies may bind non-specifically to cells expressing lowaffinity fc receptors.

Application Details

Application Notes: Flow cytometry (neat). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Concentration: 0.1 mg/ml

Buffer: Phosphate buffered saline pH 7.4, 0.09% Sodium Azide, 1% Bovine SerumAlbuminLabel: Biotin

Storage: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoidrepeated freezing and thawing. Shelf life: one year from despatch.

Restrictions: For Research Use only