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CD1d antibody (CD1d Molecule)

Details for Product anti-CD1D Antibody No. ABIN317451, Supplier: Log in to see
Antigen
  • CD1D
  • CD1.1
  • CD1.2
  • CD1D1
  • CD1A
  • R3
  • AI747460
  • Cd1a
  • Cd1d
  • Ly-38
  • Cd1
  • CD1d molecule
  • CD1c molecule
  • CD1D antigen, d polypeptide
  • CD1d1 antigen
  • CD1d1 molecule
  • CD1D
  • CD1C
  • Cd1d1
Alternatives
anti-Human CD1d antibody for Immunocytochemistry
Reactivity
Human
106
82
35
Host
Mouse
80
64
53
Clonality (Clone)
Monoclonal ()
Conjugate
This CD1d antibody is un-conjugated
18
16
13
5
4
4
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
102
84
62
48
44
37
19
18
12
5
5
4
4
2
1
1
Options
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Immunogen Beta G2 - CD1d fusion protein
Clone NOR3-2
Isotype IgG1
Specificity This antibody recognizes the CD1d gene product, a 49 kDa heavy chain associated with Beta 2 microglobulin on cortical thymocytes. Beta 2 microglobulin independent expression of CD1d has also been demonstrated on human intestinal epithelial cells.
Characteristics Synonyms: R3G1, T-cell surface glycoprotein CD1d
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Alternative Name CD1d (CD1D Antibody Abstract)
Background CD1c is a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin.CD1c is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail.Synonyms: R3G1, T-cell surface glycoprotein CD1d
Gene ID 912
UniProt P15813
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
Application Notes Immunohistochemistry on frozen sections. Immunoprecipitation. Does not work on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline 0.09 % Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2 - 8 °C up to one month or (in aliquots) at -20 °C forlonger. Avoid repeated freezing and thawing. Should this product contain a precipitate werecommend microcentrifugation before use.
Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
Flow Cytometry (FACS) image for anti-CD1d antibody (CD1d Molecule) (ABIN317451) anti-CD1d Molecule (CD1D) antibody
Background publications Zeissig, Dougan, Barral, Junker, Chen, Kaser, Ho, Mandel, McIntyre, Kennedy, Painter, Veerapen, Besra, Cerundolo, Yue, Beladi, Behar, Chen, Gumperz, Breckpot, Raper, Baer, Exley, Hegele, Cuchel et al.: "Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function. ..." in: The Journal of clinical investigation, Vol. 120, Issue 8, pp. 2889-99, 2010 (PubMed).

Moll, Andersson, Smed-Sörensen, Sandberg: "Inhibition of lipid antigen presentation in dendritic cells by HIV-1 Vpu interference with CD1d recycling from endosomal compartments." in: Blood, Vol. 116, Issue 11, pp. 1876-84, 2010 (PubMed).

Spanoudakis, Hu, Naresh, Terpos, Melo, Reid, Kotsianidis, Abdalla, Rahemtulla, Karadimitris: "Regulation of multiple myeloma survival and progression by CD1d." in: Blood, Vol. 113, Issue 11, pp. 2498-507, 2009 (PubMed).

Im, Tapinos, Chae, Illarionov, Besra, DeVries, Modlin, Sieling, Rambukkana, Porcelli: "Expression of CD1d molecules by human schwann cells and potential interactions with immunoregulatory invariant NK T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 8, pp. 5226-35, 2006 (PubMed).

Agea, Russano, Bistoni, Mannucci, Nicoletti, Corazzi, Postle, De Libero, Porcelli, Spinozzi: "Human CD1-restricted T cell recognition of lipids from pollens." in: The Journal of experimental medicine, Vol. 202, Issue 2, pp. 295-308, 2005 (PubMed).

Bonish, Jullien, Dutronc, Huang, Modlin, Spada, Porcelli, Nickoloff: "Overexpression of CD1d by keratinocytes in psoriasis and CD1d-dependent IFN-gamma production by NK-T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 7, pp. 4076-85, 2000 (PubMed).