Neurofibromin 1 antibody

Catalog No. ABIN317682

Product Details anti-Neurofibromin 1 Antibody

Target: Neurofibromin 1 (NF1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neurofibromin 1 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody detects endogenous levels of Neurofibromin protein.(region surrounding Arg1575)

Purification: Affinity Chromatography using epitope-specific immunogen.

Application Details

Application Notes: ELISA: 1/20000-1/40000. Western Blot: 1/500-1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 containing 0.05 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Neurofibromin 1

Target: Neurofibromin 1 (NF1)

Alternative Name: Neurofibromin (NF1 Products)

Synonyms: NFNS antibody, VRNF antibody, WSS antibody, CG8318 antibody, Dmel\\CG8318 antibody, NF-1 antibody, NF1 antibody, Nf-1 antibody, dNF1 antibody, nf1 antibody, fe06d03 antibody, hm:zehn0874 antibody, wu:fe06d03 antibody, zehn0874 antibody, AW494271 antibody, E030030H24Rik antibody, neurofibromin 1 antibody, Neurofibromin 1 antibody, neurofibromin 1a antibody, neurofibromin antibody, putative neurofibromin antibody, NF1 antibody, Nf1 antibody, nf1a antibody, LOC593418 antibody, LOC5570549 antibody, CpipJ_CPIJ011774 antibody, Smp_148460 antibody

Background: Neurofibromatosis type 1 (NF1), or von Reckinghausen neurofibromatosis, is one of the most common autosomal dominant disorders in humans. Early linkage analysis mapped the NF1 gene to chromosome 17. The predicted NF1 transcript encodes a 2818 amino acid protein designated NF1GRP. By sequence analysis, similarity has been demonstrated within a small region of NF1GRP and members of the Ras GAP gene family. Functionally, NF1GRP was shown by biochemical analysis involving RAS-GAP hydrolysis and functional complementation in yeast to further resemble GAP protein. The NF1 protein is expressed at relatively constant levels in a broad range of cell lines and tissues including brain, lung, liver, kidney, spleen, muscle and colon. Although little is known regarding the function of NF1GRP, the homology with the catalytic domain of proteins with GTPase activity suggests that the NF1GRP may also interact in vivo with Ras proteins.Synonyms: NF-1, NF1

Molecular Weight: approx. 319 kDa

Gene ID: 4763

NCBI Accession: NP_000258

UniProt: P21359

Pathways: cAMP Metabolic Process, Regulation of long-term Neuronal Synaptic Plasticity