BAI1 antibody (Brain-Specific Angiogenesis Inhibitor 1)

Details for Product anti-BAI1 Antibody No. ABIN317742, Supplier: Log in to see
Antigen
  • BAI1
  • GDAIF
  • B830018M07Rik
  • R75078
  • mKIAA4089
  • brain-specific angiogenesis inhibitor 1
  • BAI1
  • Bai1
Alternatives
anti-Human BAI1 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Reactivity
Human, Mouse (Murine)
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Host
Rabbit
85
Clonality
Polyclonal
Conjugate
This BAI1 antibody is un-conjugated
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Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Options
Supplier
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Specificity This antibody detects endogenous levels of BAI-1 protein.(region surrounding Gln732)
Purification Affinity Chromatography using epitope-specific immunogen
Alternative Name BAI1 (BAI1 Antibody Abstract)
Background Brain-specific angiogenesis inhibitors, including BAI-1, BAI-2 and BAI-3, are integral membrane proteins belonging to the G protein-coupled receptor 2 family. In addition to inhibiting angiogenesis in the brain, BAI proteins are also expressed in the heart, thymus, skeletal muscle, and a variety of cell lines. BAI-1 protein is specifically expressed in the brain and found to localize to the cytoplasm and membrane in neuronal cells of the cerebral cortex. Reduced expression of BAI-1 in some glioblastoma cell lines and cancer tissues implicates the functional role of BAI-1 as an inhibitor of angiogenesis. The exact mechanisms underlying BAI-1 anti-angiogenetic activity are still being investigated. BAI-1 may be involved in mediating the p53 signal in suppression of glioblastoma, as well as in cell adhesion and signal transduction. Additional research shows an inverse correlation with vascularization and BAI-1 expression in both colorectal carcinomas and pulmonary adenocarcinomas.Synonyms: BAI-1, Brain-specific angiogenesis inhibitor 1
Molecular Weight approx. 174 kDa
Gene ID 575
NCBI Accession NP_001693
UniProt O14514
Research Area Cardiovascular, Angiogenesis
Pathways p53 Signaling
Application Notes ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline (PBS), pH ~7.2 with 0.05 % Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-Brain-Specific Angiogenesis Inhibitor 1 (BAI1) antibody (ABIN317742) anti-Brain-Specific Angiogenesis Inhibitor 1 (BAI1) antibody
 image for anti-Brain-Specific Angiogenesis Inhibitor 1 (BAI1) antibody (ABIN317742) anti-Brain-Specific Angiogenesis Inhibitor 1 (BAI1) antibody (Image 2)
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