GTPBP1 antibody

Catalog No. ABIN317811

Product Details anti-GTPBP1 Antibody

Target: GTPBP1 (GTP Binding Protein 1 (GTPBP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GTPBP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificity: GBP1 antibody detects endogenous levels of GBP1 protein.(region surrounding Glu99)

Purification: Affinity chromatography

Application Details

Application Notes: ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for GTPBP1

Target: GTPBP1 (GTP Binding Protein 1 (GTPBP1))

Alternative Name: GTP-Binding Protein 1 / GBP1 (GTPBP1 Products)

Synonyms: GP-1 antibody, GP1 antibody, HSPC018 antibody, AL022987 antibody, AW045683 antibody, C85212 antibody, Gtpbp antibody, cb858 antibody, wu:fb36e06 antibody, wu:fi39g05 antibody, zgc:66228 antibody, gtpbp1 antibody, GTP binding protein 1 antibody, GTP binding protein 1 S homeolog antibody, GTPBP1 antibody, Gtpbp1 antibody, gtpbp1 antibody, gtpbp1.S antibody

Background: GBP1 (guanylate binding protein 1) is a 592 amino acid protein member of the GTPase protein family and is able to bind specifically to guanine nucleotides such as GMP, GDP and GTP. GMP is hydrolyzed to GTP in two consecutive cleavage step, both of which are carried out by GBP1. Localized to the cytoplasm, GBP1 is expressed in endothelial cells of the vascular system and is induced by IFN-γ during macrophage induction. GBP1 is thought to regulate the expression of MMP-1, which mediates the proliferation and invasiveness of endothelial cells. GBP1 plays a key role in regulating inflammatory cytokines and provides protection against vesicular stomatitis and encephalomyocarditis viruses. GBP1 expression is highly induced in the vessels of skin diseases such as psoriasis and Kaposi's sarcoma, making it a novel cellular activation marker that characterizes inflammatory cytokines of endothelial cells.Synonyms: Guanine nucleotide-binding protein 1, HuGBP-1, Interferon-induced guanylate-binding protein 1

Molecular Weight: approx. 68 kDa

Gene ID: 2633

NCBI Accession: NP_002044

UniProt: P32455