GRID2 antibody

Catalog No. ABIN317812

Product Details anti-GRID2 Antibody

Target: GRID2 (Glutamate Receptor, Ionotropic, delta 2 (GRID2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRID2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificity: This antibody detects endogenous levels of GluR delta-2 protein.(region surrounding Gly860)

Purification: Affinity Chromatography using epitope-specific immunogen.

Application Details

Application Notes: ELISA: 1/20000 - 1/40000. Western Blot: 1/500 - 1/1000. Immunofluorescence: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 with 0.05 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for GRID2

Target: GRID2 (Glutamate Receptor, Ionotropic, delta 2 (GRID2))

Alternative Name: Glutamate Receptor delta-2 (GRID2 Products)

Synonyms: GluD2 antibody, glurd2 antibody, si:rp71-1l7.1 antibody, GRID2 antibody, B230104L07Rik antibody, GluRdelta2 antibody, Lc antibody, Lc antibody, MMS10-AC antibody, Ms10ac antibody, cpr antibody, ho antibody, nmf408 antibody, tpr antibody, glutamate receptor, ionotropic, delta 2 antibody, glutamate receptor ionotropic, delta-2 antibody, glutamate ionotropic receptor delta type subunit 2 antibody, grid2 antibody, LOC704787 antibody, GRID2 antibody, Grid2 antibody, LOC536367 antibody

Background: Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamategated, cation-specific ion channels. Kainate/AMPA receptors co-localize with NMDA receptors in many synapses and consist of seven structurally related subunits, designated GluR-1 to -7, as well as GluR-δ2. The kainate/AMPA receptors are primarily responsible for the fast excitatory neurotransmission by glutamate whereas the NMDA receptors are functionally characterized by a slow kinetic and a high permeability for Ca2+ ions. The NMDA receptors consist of five subunits: ε1, 2, 3, 4 and one ζ subunit. The ζ subunit is expressed throughout the brainstem whereas the four ε subunits display limited distribution. In mice, mutations in the gene encoding GluR-δ2 (GRID2) cause the Lurcher phenotype. The gene encoding human GluR-δ2 maps to chromosome 4q22.Synonyms: GLURD2, GRID2, GluR delta-2

Molecular Weight: approx. 113 kDa

Gene ID: 2895

NCBI Accession: NP_001501

UniProt: O43424

Pathways: Synaptic Membrane