PTGDR antibody

Catalog No. ABIN317875

Product Details anti-PTGDR Antibody

Target: PTGDR (Prostaglandin D2 Receptor (PTGDR))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTGDR antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificity: PD2R antibody detects endogenous levels of PD2R protein.(region surrounding Glu301)

Purification: Affinity chromatography

Application Details

Application Notes: ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PTGDR

Target: PTGDR (Prostaglandin D2 Receptor (PTGDR))

Alternative Name: PTGDR (PTGDR Products)

Synonyms: AS1 antibody, ASRT1 antibody, DP antibody, DP1 antibody, PTGDR1 antibody, Ptgdr antibody, Ptgdr2 antibody, PTGDR antibody, PGD antibody, prostaglandin D2 receptor antibody, prostaglandin D receptor antibody, PTGDR antibody, Ptgdrl antibody, Ptgdr antibody

Background: The prostaglandin D2 receptor is a member of the G-protein-coupled receptor (GPCR) family (subfamily: prostanoid). It has been shown to function as a prostanoid DP receptor. Its activity is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+. Knockout studies in mice suggest that the ligand of this receptor, prostaglandin D2 (PGD2), functions as a mast cell-derived mediator to trigger asthmatic responses. Prostaglandin D2 receptor has been reported to be expressed in human small intestine, colon (goblet cells), eye, and eosinophils. ESTs have been isolated from human brain libraries.Synonyms: ASRT1, PGD receptor, PGD2 receptor, Prostaglandin D2 receptor, Prostanoid DP receptor

Molecular Weight: approx. 40 kDa

Gene ID: 5729

NCBI Accession: NP_000944

UniProt: Q13258

Pathways: Thromboxane A2 Receptor Signaling