TGFBR1 antibody

Catalog No. ABIN317892

Product Details anti-TGFBR1 Antibody

Target: TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TGFBR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificity: This antibody detects endogenous levels of TGFβ RI protein.(region surrounding Glu161)

Purification: Affinity Chromatography

Application Details

Application Notes: ELISA: 1: 5000approx. 1: 10000. Western Blot: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

References for anti-TGFBR1 antibody (ABIN317892)

Trojan, Ślusarczyk, Chamera, Kotarska, Głombik, Kubera, Basta-Kaim: "The Modulatory Properties of Chronic Antidepressant Drugs Treatment on the Brain Chemokine - Chemokine Receptor Network: A Molecular Study in an Animal Model of Depression." in: Frontiers in pharmacology, Vol. 8, pp. 779, (2017) (PubMed).

Yu, Hu, Yang, Takemori, Li, Zheng, Hong, Liao, Wen: "Salt-inducible kinase 1 is involved in high glucose-induced mesangial cell proliferation mediated by the ALK5 signaling pathway." in: International journal of molecular medicine, Vol. 32, Issue 1, pp. 151-7, (2013) (PubMed).

Coy, Jiménez-Movilla, García-Vázquez, Mondéjar, Grullón, Romar: "Oocytes use the plasminogen-plasmin system to remove supernumerary spermatozoa." in: Human reproduction (Oxford, England), Vol. 27, Issue 7, pp. 1985-93, (2012) (PubMed).

Behrens, Villone, Koch, Brunner, Sorokin, Robenek, Bruckner-Tuderman, Bruckner, Hansen: "The epidermal basement membrane is a composite of separate laminin- or collagen IV-containing networks connected by aggregated perlecan, but not by nidogens." in: The Journal of biological chemistry, Vol. 287, Issue 22, pp. 18700-9, (2012) (PubMed).

Dong, Wang, Cao, Ren, Fan, He, Smith, Dong: "Nitric oxide enhances melanogenesis of alpaca skin melanocytes in vitro by activating the MITF phosphorylation." in: Molecular and cellular biochemistry, Vol. 352, Issue 1-2, pp. 255-60, (2011) (PubMed).

Ricci-Vitiani, Mollinari, di Martino, Biffoni, Pilozzi, Pagliuca, de Stefano, Circo, Merlo, De Maria, Garaci: "Thymosin beta4 targeting impairs tumorigenic activity of colon cancer stem cells." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 24, Issue 11, pp. 4291-301, (2010) (PubMed).

Target Details for TGFBR1

Target: TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))

Alternative Name: TGFBR1 / ALK-5 (TGFBR1 Products)

Synonyms: AAT5 antibody, ACVRLK4 antibody, ALK-5 antibody, ALK5 antibody, LDS1A antibody, LDS2A antibody, MSSE antibody, SKR4 antibody, TGFR-1 antibody, aat5 antibody, acvrlk4 antibody, alk-5 antibody, alk5 antibody, lds1a antibody, lds2a antibody, skr4 antibody, tgfr-1 antibody, TGFBR1 antibody, x-trr1 antibody, AU017191 antibody, Alk-5 antibody, TbetaR-I antibody, TbetaRI antibody, Alk5 antibody, Skr4 antibody, Tgfr-1 antibody, tbetaR-I antibody, tgfbr1 antibody, zgc:123263 antibody, transforming growth factor beta receptor 1 antibody, transforming growth factor beta receptor I antibody, transforming growth factor beta receptor I S homeolog antibody, transforming growth factor, beta receptor I antibody, transforming growth factor, beta receptor 1 antibody, transforming growth factor, beta receptor 1 a antibody, TGFBR1 antibody, tgfbr1 antibody, tgfbr1.S antibody, Tgfbr1 antibody, tgfbr1a antibody

Background: Three members of the TGF beta family, TGF beta 1, TGF beta 2 and TGF beta 3, are known in mammals. TGF betas mediate their activity by high affinity binding to the type 2 receptor, which requires both its kinase activity and association with members of a series of related type 1 receptors called activin receptor like kinase (ALK) 1 to 6. Of these, only ALK5 has been shown to represent a functional TGF beta type 1 receptor, but only ALK2 and ALK4 bind activin with high affinity. TGF beta R3 binds TGF beta and retains TGF beta for presentation to the signaling receptors.Synonyms: ALK5, Activin receptor-like kinase 5, SKR4, Serine/threonine-protein kinase receptor R4, TGF-beta receptor type-1, TGF-beta type I receptor, TGFR-1, TbetaR-I, Transforming growth factor-beta receptor type I

Molecular Weight: approx. 55 kDa

Gene ID: 7046

NCBI Accession: NP_001124388

UniProt: P36897

Pathways: Growth Factor Binding