TUBGCP5 antibody

Catalog No. ABIN317909

Product Details anti-TUBGCP5 Antibody

Target: TUBGCP5 (Tubulin, gamma Complex Associated Protein 5 (TUBGCP5))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TUBGCP5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: GCP5 antibody detects endogenous levels of GCP5 protein.(region surrounding Ile779)

Purification: Affinity chromatography

Application Details

Application Notes: ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for TUBGCP5

Target: TUBGCP5 (Tubulin, gamma Complex Associated Protein 5 (TUBGCP5))

Alternative Name: TUBGCP5 (TUBGCP5 Products)

Synonyms: wu:fa03b04 antibody, wu:fe01d03 antibody, zgc:110217 antibody, GCP5 antibody, B130010C12Rik antibody, mKIAA1899 antibody, tubulin gamma complex associated protein 5 antibody, tubulin, gamma complex associated protein 5 antibody, TUBGCP5 antibody, tubgcp5 antibody, Tubgcp5 antibody

Background: The γ-Tubulin complex is composed of γ Tubulin and the γ-Tubulin complexassociated proteins GCP2, GCP3, GCP4, GCP5 and GCP6, all of which are essential components of microtubule organizing centers. γ-Tubulin complex components are localized to both the centrosome, where they are involved in microtubule nucleation, and to the cytoplasm, where they exist as soluble complexes that can be recruited to the centrosome as needed. Although the GCP proteins are related, they have distinct roles which contribute to the proper function of the γ-Tubulin complex. GCP5 (γ-Tubulin complex component 5), also known as TUBGCP5, is a 1,024 amino acid member of the γ-Tubulin complex and is highly expressed in heart and skeletal muscle. Defects in the gene encoding GCP5 are implicated in Prader-Willi syndrome (PWS), a rare genetic disorder associated with obesity, compulsive behavior and lower intellectual ability.Synonyms: GCP-5, GCP5, Gamma-tubulin complex component 5, KIAA1899

Molecular Weight: approx. 118 kDa

Gene ID: 114791

NCBI Accession: NP_001096080

UniProt: Q96RT8

Pathways: M Phase