POMC antibody (N-Term)

Catalog No. ABIN318390

Product Details anti-POMC Antibody

Target: POMC (Proopiomelanocortin (POMC))

Binding Specificity: AA 1-24, N-Term

Reactivity: Human, Vicia faba

Host: Rabbit

Clonality: Polyclonal

Conjugate: This POMC antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Sequence: SYSMEHFRWG KPVGKKRRPV KVYP

Specificity: This antibody reacts to ACTH.

Purification: Purified Ig prepared by affinity chromatography on Protein G

Immunogen: Synthetic peptide corresponding to the amino acids 1-24 of ACTH conjugated to Keyhole limpet Haemocyanin.

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry on frozen sections: 1/100 - 1/200. Immunohistochemistry on paraffin sections: 1/100 - 1/200. ELISA: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 5.0 mg/mL

Buffer: Phosphate buffered saline pH 7.4 containing 0.09 % Sodium Azide (NaN3)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for POMC

Target: POMC (Proopiomelanocortin (POMC))

Alternative Name: POMC (POMC Products)

Synonyms: MSH antibody, ACTH antibody, pomc antibody, SI:bZ36D5.1 antibody, SI:bZ36D5.4 antibody, si:bz36d5.2 antibody, BE antibody, Beta-LPH antibody, Clip antibody, Gamma-LPH antibody, Npp antibody, Pomc-1 antibody, Pomc1 antibody, alpha-MSH antibody, alphaMSH antibody, beta-MSH antibody, gamma-MSH antibody, CLIP antibody, LPH antibody, NPP antibody, POC antibody, Pomc2 antibody, proopiomelanocortin a antibody, pro-opiomelanocortin-alpha antibody, proopiomelanocortin antibody, pomca antibody, Pomc antibody, POMC antibody

Background: ACTH occurs in cells of the anterior pituitary and in neurons in brain. It regulates the corticosteroid production in the adrenal cortex. Beta endorphin and Met enkephalin are endogenous opiates. MSH (melanocyte stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes.Synonyms: Adrenocorticotropic hormone, Corticotropin, POMC

Gene ID: 5443

NCBI Accession: NP_000930

UniProt: P01189

Pathways: Metabolism of Steroid Hormones and Vitamin D, Peptide Hormone Metabolism, Hormone Activity, Feeding Behaviour