Tetanus Toxin antibody
TetX
Reactivity: Clostridium tetani
WB, EIA
Host: Goat
Polyclonal
unconjugated
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- Target See all Tetanus Toxin (TetX) Antibodies
- Tetanus Toxin (TetX)
- Reactivity
- Clostridium tetani
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Host
- Goat
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Clonality
- Polyclonal
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Conjugate
- This Tetanus Toxin antibody is un-conjugated
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Application
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Specificity
- This antibody detects the tetanus toxin which is produced by the soil micro-organism Clostridium tetani. C. tetani infection results in its systemic growth and secretion of tetanus, which causes muscle spasms by inhibiting neurotransmitter release. The antibody also reacts with the C-fragment of tetanus toxin.
- Purification
- Affinity Chromatography.
- Immunogen
- Tetanus Exotoxin
- Isotype
- IgG
- Top Product
- Discover our top product TetX Primary Antibody
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- Application Notes
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ELISA: 1g/mL. Western Blot: 1/100 - 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 5.0 mg/mL
- Buffer
- PBS pH 7.2 containing 0.09 % Sodium Azide as preservative.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Target
- Tetanus Toxin (TetX)
- Alternative Name
- Tetanus Toxin (TetX Products)
- Target Type
- Bacteria
- Background
- Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the 76-Gln-|-Phe-77 bond of synaptobrevin-2. The precursor polypeptide is subsequently cleaved to yield subchains L and H. These remain linked by a disulfide bridge and are non-toxic after separation.Synonyms: Clostridium tetani toxin, tetX
- Gene ID
- 1061100
- NCBI Accession
- NP_783831
- UniProt
- P04958
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