Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (pTyr1472) antibody

Details for Product No. ABIN318700
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Antigen
Synonyms NMDAR2B, GluN2B, MRD6, NR2B, hNR3, nmdar2b, nr2b, AW490526, Nmdar2b
Epitope
pTyr1472
(52), (45), (43), (39), (37), (28), (23), (23), (17), (5), (5), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Cow (Bovine), Dog (Canine), Chicken, Human, Monkey, Mouse (Murine), Rat (Rattus), Zebrafish (Danio rerio)
(320), (297), (256), (137), (135), (134), (70), (17), (7), (6), (4), (3), (3), (2), (2)
Host
Rabbit
(310), (59), (6)
Clonality
Polyclonal
Conjugate
Un-conjugated
(11), (11), (11), (9), (9), (9), (9), (9), (9), (9), (9), (6), (6), (6), (6), (6), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application
Western Blotting (WB)
(241), (94), (86), (83), (75), (71), (54), (38), (22), (11), (4), (1), (1)
Pubmed 4 references available
Quantity 0.1 mL
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Catalog No. ABIN318700
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Immunogen Synthetic phosphopeptide corresponding to an amino acid sequence within the NR2B subunit of the NMDA receptor, which includes phosphorylated Tyr1472.
Isotype IgG
Specificity This antibody specifically recognises the 180kDa NR2B subunit of the NMDA (N-methyl-D- aspartate) receptor when phosphorylated at Tyr1472.
Purification Purified
Alternative Name NMDAR2B
Background Receptors for NMDA belong to a group of ionotropic glutamate receptors which play a key role in the mediation of glutamate neurotransmission within the mammalian central nervous system (CNS), including involvement in memory and learning processes. Several antagonists and agonists of NMDA receptors (NMDAR) have been identified, including the glutamate analogue Homoquinolinic acid, which displays a higher affinity for NR2B- containing NMDAR. Properties of NMDAR include modulation by glycine, inhibition by Zn2+, voltage-dependent Mg2+ blockade and high Ca2+ permeability. The involvement of NMDAR in the CNS has become a focus area for neurodegenerative diseases such as Alzheimers disease and also epilepsy and ischemic neuronal cell death.
Alternate names: GRIN2B, Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, N-methyl-D-aspartate receptor subunit 3, NMDA Receptor 2B
Gene ID 2904
NCBI Accession NP_000825
UniProt Q13224
Research Area Neurology, Neurotransmitters, Receptors
Application Notes Western Blot: 1: 1000, detects a band of approximately 180 kDa in rat brain hippocampallysates. This antibody also labels proteins of 65kDa and 115kDa. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer 10mM HEPES pH7.5. containing 0.09% Sodium Azide, 0.01% Bovine Serum Albumin and 50% Glycerol
Preservative Sodium azide
Precaution of Use This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Ishii, Moriyoshi, Sugihara et al.: "Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits." in: The Journal of biological chemistry, Vol. 268, Issue 4, pp. 2836-43, 1993 (PubMed).

Rosenblum, Dudai, Richter-Levin: "Long-term potentiation increases tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit 2B in rat dentate gyrus in vivo." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 19, pp. 10457-60, 1996 (PubMed).

Takasu, Dalva, Zigmond et al.: "Modulation of NMDA receptor-dependent calcium influx and gene expression through EphB receptors." in: Science (New York, N.Y.), Vol. 295, Issue 5554, pp. 491-5, 2002 (PubMed).

Popke: "From anticholinesterase toxicity to Alzheimer's disease: important interactions of cholinergic and NMDA receptor systems." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 72, Issue 2, pp. 185-7, 2003 (PubMed).

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