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HRK antibody (Middle Region)

HRK Reactivity: Human, Mouse, Rat WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN318751
  • Target See all HRK Antibodies
    HRK (Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK))
    Binding Specificity
    • 15
    • 13
    • 7
    • 2
    • 2
    • 1
    Middle Region
    Reactivity
    • 29
    • 23
    • 18
    • 2
    • 2
    • 2
    • 1
    Human, Mouse, Rat
    Host
    • 44
    Rabbit
    Clonality
    • 44
    Polyclonal
    Conjugate
    • 13
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This HRK antibody is un-conjugated
    Application
    • 18
    • 14
    • 13
    • 13
    • 9
    • 5
    • 3
    • 1
    • 1
    Western Blotting (WB)
    Specificity
    This antibody detects Harakiri (HRK), also known as DP5.
    Purification
    Purified
    Immunogen
    15 amino acid peptide from near the centre of human HRK (NP_003797).
    Isotype
    IgG
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    Discover our top product HRK Primary Antibody
  • Application Notes
    Western Blot: 2 - 5g/mL, detects a band of approximately 13 kDa in mouse pancreas tissuelysate.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Precaution of Use
    This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    HRK (Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK))
    Alternative Name
    Harakiri / HRK (HRK Products)
    Synonyms
    DP5 antibody, HARAKIRI antibody, AI838259 antibody, Bid3 antibody, harakiri antibody, Dp5 antibody, harakiri, BCL2 interacting protein antibody, harakiri, BCL2 interacting protein (contains only BH3 domain) antibody, HRK antibody, Hrk antibody
    Background
    HRK is a BH3 only protein of the Bcl-2 family, which promotes Bax dependent apoptosis. HRK regulates apoptosis through its interaction with the anti-apoptotic proteins Bcl-2 and Bcl-XL, and in conjunction to the mitochondrial pore forming protein p32. HRK is thought to have a specific role in initiating neuronal and haematopoietic cell apoptosis, in particular to growth factor deprivation. Aberrant methylation of HRK is frequently detected in primary colorectal cancers. Despite its predicted molecular weight, HRK often migrates at 12-15kD.Synonyms: Activator of apoptosis harakiri, BH3-interacting domain-containing protein 3, BID3, Neuronal death protein DP5
    Gene ID
    8739
    NCBI Accession
    NP_003797
    UniProt
    O00198
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