FAIM3 antibody (C-Term)

Catalog No. ABIN318759

Product Details anti-FAIM3 Antibody

Target: FAIM3 (Fas Apoptotic Inhibitory Molecule 3 (FAIM3))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FAIM3 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody detects an epitope within the C-terminal (CT) region of Human Toso, also known as Fas Apoptotic Inhibitory Molecule 3 (FAIM3). In Western Bloting, This antibody detects a band of approximately 43 kDa in Human lung tissue lysate.

Cross-Reactivity (Details): Species reactivity (expected):Rat and Mouse.
Species reactivity (tested):Human.

Purification: Affinity Chromatography

Immunogen: A 13 amino acid peptide from near the carboxy terminus of Human Toso. Genename: TOSO

Isotype: IgG

Application Details

Application Notes: Western Blot: 1 - 2g/mL, detects a band of approximately 43 kDa in human lung tissuelysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS, 0.02 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for FAIM3

Target: FAIM3 (Fas Apoptotic Inhibitory Molecule 3 (FAIM3))

Alternative Name: FAIM3 / TOSO (FAIM3 Products)

Synonyms: FAIM3 antibody, FCMR antibody, TOSO antibody, 1810037B05Rik antibody, FcmuR antibody, Toso antibody, Fc fragment of IgM receptor antibody, FCMR antibody, Fcmr antibody

Background: Toso is expressed by lymphoid and haematopoietic cells and is up-regulated by T-cell activation. Toso expressing cells have increased resistance to Fas-, FADD-, and TNFalpha-induced apoptosis. Toso is membrane bound, and is thought to directly bind to FADD, disrupting DISC formation and thus inhibiting caspase-8 activation. Toso is a potential proto-oncogene, and could be a therapeutic target for use in the treatment of autoimmune diseases. Despite its predicted molecular weight, Toso often migrates at 60 kDa in SDS PAGE.Synonyms: Fas apoptotic inhibitory molecule 3, Regulator of Fas-induced apoptosis Toso

Gene ID: 9214

NCBI Accession: NP_001135945

UniProt: O60667