HAVCR1 antibody (Middle Region)

Catalog No. ABIN318765

Product Details anti-HAVCR1 Antibody

Target: HAVCR1 (Hepatitis A Virus Cellular Receptor 1 (HAVCR1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HAVCR1 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody detects T cell immunoglobulin mucin-1 (TIM-1), which was first identified as the receptor used by hepatitis A for viral entry (it is also known as the hepatitis A virus cellular receptor- HAVCR).

Purification: Purified

Immunogen: 16 amino acid peptide sequence near the centre of human TIM-1.

Isotype: IgG

Application Details

Application Notes: Western Blot: 1.0 - 2.0g/mL, detects a band of approximately 49 kDa in human uterustissue lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline containing 0.02 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for HAVCR1

Target: HAVCR1 (Hepatitis A Virus Cellular Receptor 1 (HAVCR1))

Alternative Name: TIMD1 / HAVCR1 (HAVCR1 Products)

Target Type: Virus

Background: TIM-1 is a key cell surface protein that binds TIM-4, leading to T cell proliferation and T helper type 2 (Th2) cytokine production. TIM-1 has also been shown to bind and activate macrophages. Two splice variants for human TIM-1 exist, TIM-1a is predominantly expressed in the liver, whilst TIM-1b is expressed in the kidney. Expression of TIM-1 in the kidney is thought to be upregulated in damaged tissue, and is thought to assist healing. TIM-1 polymorphisms are associated with asthma.Synonyms: HAVCR-1, Hepatitis A virus cellular receptor 1, T cell immunoglobulin and mucin domain-containing protein 1, T cell membrane protein 1, TIM-1, TIM1, TIMD-1

Gene ID: 26762

NCBI Accession: NP_001092884

UniProt: Q96D42