You are viewing an incomplete version of our website. Please click to reload the website as full version.

BMI1 antibody (BMI1 Polycomb Ring Finger Oncogene) (Middle Region)

Details for Product anti-BMI1 Antibody No. ABIN318769, Supplier: Log in to see
Antigen
  • AW546694
  • Bmi-1
  • BMI-1
  • bmi1
  • FLVI2/BMI1
  • pcgf4
  • Pcgf4
  • PCGF4
  • psc1
  • RNF51
  • wu:fb17g03
  • wu:fd18f06
Alternatives
anti-Human BMI1 antibody for Enzyme Immunoassay
Epitope
Middle Region
30
23
19
12
8
6
5
5
5
5
4
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
267
102
40
10
7
5
4
4
2
2
2
1
1
1
Host
Rabbit
170
99
18
Clonality
Polyclonal
Conjugate
This BMI1 antibody is un-conjugated
14
13
10
9
7
7
3
3
3
3
3
3
3
2
2
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
245
107
81
66
55
29
28
22
21
6
6
4
3
2
1
1
1
1
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Available images

Immunogen 15 amino acid peptide sequence near the centre of human BMI-1.
Isotype IgG
Specificity This antibody recognises 37 kDa polycomb complex protein BMI-1, involved in segment specification, cell growth and maintenance, transcriptional regulation and chromatin modification.
Purification Purified
Alternative Name BMI-1 / RNF51 (BMI1 Antibody Abstract)
Background BMI-1 is a proto-oncogene which cooperates with the myc oncogene to produce B-lymphomas. It is required in the regulation of normal adult and leukaemic stem cells, making BMI-1 a potential target for stem cell proliferation and anti-cancer therapies. BMI-1 represses transcription at the ink4 locus which contains tumour suppressors p16 and p19Arf. BMI-1 is a component of the Polycomb group (PcG) multiprotein PRC1 complex which ubiquitinates histone-2A at lys119, resulting in a heritable change in the ability of chromatin to express genes. BMI-1 is also required to stimulate the E3 ubiquitin ligase activity of RNF2/RING2 within the PRC1 complex.Synonyms: BMI1, PCGF4, Polycomb group RING finger protein 4, RING finger protein 51
Gene ID 100532731
NCBI Accession NP_001190991
UniProt P35226
Pathways Cell Division Cycle
Application Notes Western Blot: 0.5 - 1.0g/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline containing 0.02 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-BMI1 antibody (BMI1 Polycomb Ring Finger Oncogene) (Middle Region) (ABIN318769) anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (Middle Region) antibody
 image for anti-BMI1 antibody (BMI1 Polycomb Ring Finger Oncogene) (Middle Region) (ABIN318769) anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (Middle Region) antibody (Image 2)
Background publications Lessard, Sauvageau: "Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells." in: Nature, Vol. 423, Issue 6937, pp. 255-60, 2003 (PubMed).