BMI1 antibody (BMI1 Polycomb Ring Finger Oncogene) (Middle Region)

Details for Product anti-BMI1 Antibody No. ABIN318769, Supplier: Log in to see
Antigen
  • bmi1
  • pcgf4
  • psc1
  • wu:fb17g03
  • wu:fd18f06
  • FLVI2/BMI1
  • PCGF4
  • RNF51
  • AW546694
  • Bmi-1
  • Pcgf4
  • BMI-1
  • BMI1 polycomb ring finger oncogene
  • B lymphoma Mo-MLV insertion region 1a
  • Bmi1 polycomb ring finger oncogene
  • LOC100230513
  • LOC100358360
  • bmi1a
  • BMI1
  • Bmi1
Alternatives
anti-Human BMI1 antibody for Immunofluorescence (fixed cells)
Epitope
Middle Region
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Reactivity
Human, Mouse (Murine), Rat (Rattus)
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Host
Rabbit
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Clonality
Polyclonal
Conjugate
This BMI1 antibody is un-conjugated
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Application
Immunofluorescence (IF), Western Blotting (WB)
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Options
Supplier
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Immunogen 15 amino acid peptide sequence near the centre of human BMI-1.
Isotype IgG
Specificity This antibody recognises 37 kDa polycomb complex protein BMI-1, involved in segment specification, cell growth and maintenance, transcriptional regulation and chromatin modification.
Purification Purified
Alternative Name BMI-1 / RNF51 (BMI1 Antibody Abstract)
Background BMI-1 is a proto-oncogene which cooperates with the myc oncogene to produce B-lymphomas. It is required in the regulation of normal adult and leukaemic stem cells, making BMI-1 a potential target for stem cell proliferation and anti-cancer therapies. BMI-1 represses transcription at the ink4 locus which contains tumour suppressors p16 and p19Arf. BMI-1 is a component of the Polycomb group (PcG) multiprotein PRC1 complex which ubiquitinates histone-2A at lys119, resulting in a heritable change in the ability of chromatin to express genes. BMI-1 is also required to stimulate the E3 ubiquitin ligase activity of RNF2/RING2 within the PRC1 complex.Synonyms: BMI1, PCGF4, Polycomb group RING finger protein 4, RING finger protein 51
Gene ID 100532731
NCBI Accession NP_001190991
UniProt P35226
Pathways Cell Division Cycle, Autophagy
Application Notes Western Blot: 0.5 - 1.0g/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline containing 0.02 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-BMI1 antibody (BMI1 Polycomb Ring Finger Oncogene) (Middle Region) (ABIN318769) anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (Middle Region) antibody
 image for anti-BMI1 antibody (BMI1 Polycomb Ring Finger Oncogene) (Middle Region) (ABIN318769) anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (Middle Region) antibody (Image 2)
Background publications Lessard, Sauvageau: "Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells." in: Nature, Vol. 423, Issue 6937, pp. 255-60, 2003 (PubMed).