UNG antibody (N-Term)

Catalog No. ABIN318787

Product Details anti-UNG Antibody

Target: UNG (Uracil-DNA Glycosylase (UNG))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UNG antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody recognises uracil-DNA glycosylase 1 (UNG1), a member of the uracil-DNA glycosylase and cyclin family.

Purification: Purified

Immunogen: 14 amino acid peptide sequence near the amino terminus of human UNG1.

Isotype: IgG

Application Details

Application Notes: Western Blot: 0.5 - 1.0g/mL, detects a band of approximately 34.6 kDa in C2C/2 celllysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline containing 0.02 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for UNG

Target: UNG (Uracil-DNA Glycosylase (UNG))

Abstract: UNG Products

Synonyms: DGU antibody, HIGM4 antibody, HIGM5 antibody, UDG antibody, UNG1 antibody, UNG15 antibody, UNG2 antibody, ung antibody, zgc:56102 antibody, PSPTO4236 antibody, BA5648 antibody, ECK2578 antibody, JW2564 antibody, An02g14790 antibody, AO090001000732 antibody, DDBDRAFT_0204444 antibody, DDBDRAFT_0214910 antibody, DDB_0204444 antibody, DDB_0214910 antibody, uracil-DNA glycosylase antibody, uracil DNA glycosylase antibody, uracil DNA glycosylase a antibody, uracil-DNA glycosylase Ung antibody, uracil-DNA-glycosylase antibody, uracil DNA glycosylase L homeolog antibody, uracil glycosylase antibody, temporal expression: early antibody, ung antibody, ung2 antibody, Ung antibody, UNG antibody, unga antibody, STY2840 antibody, ung.L antibody, ANI_1_3358024 antibody, AOR_1_1318164 antibody, uglA antibody, Arnit_2731 antibody, D4R antibody

Target Type: Viral Protein

Background: Two isoforms of UNG exist, isoform 1 is expressed in the mitochondria of in skeletal muscle, heart and testicles while isoform 2 (UNG2) is more abundant in proliferating tissues and expressed in the nucleus. Uracil residues can be misincorporated into DNA by DNA polymerase or by deamination of cytosine. UNG1 is a major enzyme in base excision repair, excising the misincorporated uracil residues in a process crucial to increasing immunoglobulin diversity. In association with activation-induced cytosine deaminase, UNG is also essential to the generation of strand breaks that initiate class switch recombination. UNG is also involved in the innate immune response against retroviral infections, HIV-1 accessory protein Vpr induces the rapid degradation of UNG2.Synonyms: DGU, UDG, UNG1, UNG15

Gene ID: 7374

NCBI Accession: NP_003353

UniProt: P13051

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response