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MAP2K5 antibody (pSer311, pThr315)

MAP2K5 Reactivity: Human, Mouse, Rat, Dog, Chicken, Cow, Zebrafish (Danio rerio), Xenopus laevis, Monkey WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN318850
  • Target See all MAP2K5 Antibodies
    MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))
    Binding Specificity
    • 28
    • 28
    • 16
    • 15
    • 15
    • 15
    • 9
    • 9
    • 9
    • 8
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    pSer311, pThr315
    Reactivity
    • 130
    • 58
    • 54
    • 8
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Dog, Chicken, Cow, Zebrafish (Danio rerio), Xenopus laevis, Monkey
    Host
    • 142
    • 6
    Rabbit
    Clonality
    • 133
    • 15
    Polyclonal
    Conjugate
    • 44
    • 11
    • 10
    • 9
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    This MAP2K5 antibody is un-conjugated
    Application
    • 113
    • 66
    • 65
    • 50
    • 19
    • 15
    • 14
    • 12
    • 8
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Specificity
    This antibody specifically recognises 49 kDa MEK5, also known as MAP2K5, when phosphorylated at Ser311 and Thr315. Activation of MEK5 itself is regulated by upstream MAP3K3/MEKK3, and phosphorylation of MEK5 at both the Ser311 and Thr315 sites has been implicated in cell proliferation.
    Purification
    Purified
    Immunogen
    Synthetic phosphopeptide corresponding to an amino acid sequence within MEK5 , which includes phoshorylated Ser311 and Thr315.
    Isotype
    IgG
    Top Product
    Discover our top product MAP2K5 Primary Antibody
  • Application Notes
    Western Blot: 1: 1000, detects a band of approximately 49 kDa in rat testes cell lysates.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    10 mM Hepes pH 7.5 containing 0.09 % Sodium Azide (NaN3), 0.01 % Bovine Serum Albumin, 50 % Glycerol
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))
    Alternative Name
    MAP2K5 (MAP2K5 Products)
    Synonyms
    Mek5 antibody, HsT17454 antibody, MAPKK5 antibody, MEK5 antibody, PRKMK5 antibody, AI324775 antibody, AI428457 antibody, Mapkk5 antibody, Prkmk5 antibody, fb73f02 antibody, wu:fb73f02 antibody, zgc:172137 antibody, ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5 antibody, ATMAP2K_ALPHA antibody, ATMEK5 antibody, ATMKK5 antibody, MAP KINASE KINASE 5 antibody, MAP kinase kinase 5 antibody, MAP2K_A antibody, mitogen activated protein kinase kinase 5 antibody, mitogen-activated protein kinase kinase 5 antibody, mitogen-activated protein kinase kinase 5 L homeolog antibody, MAP kinase kinase 5 antibody, Map2k5 antibody, MAP2K5 antibody, map2k5 antibody, map2k5.L antibody, MKK5 antibody
    Background
    MEK5 is a dual specificity serine/threonine protein kinase belonging to the MAP kinase kinase family, which acts as a key regulator in a mitogen-activated protein (MAP) kinase cascade, and hence growth factor-induced cellular stimulation. MEK5 exists in naturally occurring MEK5alpha and MEK5beta splice variants, the former of which is known to specifically activate/regulate MAPK7/ERK5/BMK1, whilst the latter may act as a suppressor of MAPK7 activation.Synonyms: Dual specificity mitogen-activated protein kinase kinase 5, MAP kinase kinase 5, MAPKK 5, MEK5, MKK5
    Gene ID
    5607
    NCBI Accession
    NP_001193733
    UniProt
    Q13163
    Pathways
    MAPK Signaling, Neurotrophin Signaling Pathway
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