PTK7 antibody (N-Term)

Catalog No. ABIN318893

Product Details anti-PTK7 Antibody

Target: PTK7 (PTK7 Protein tyrosine Kinase 7 (PTK7))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTK7 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody recognises Protein tyrosine kinase-like 7 (PTK7).

Purification: Antisera to human PTK7 (NT) were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.

Immunogen: A 15 amino acid peptide located near the N-terminal region of human PTK7.

Isotype: IgG

Application Details

Application Notes: Western Blot: 0.5 - 1.0g/mL, detects a band of approximately 86 kDa in colon tissuelysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline containing 0.02 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PTK7

Target: PTK7 (PTK7 Protein tyrosine Kinase 7 (PTK7))

Alternative Name: PTK7 / CCK4 (PTK7 Products)

Synonyms: PTK7 antibody, CCK-4 antibody, CCK4 antibody, Srf antibody, 8430404F20Rik antibody, chz antibody, mPTK7/CCK4 antibody, KLG antibody, protein tyrosine kinase 7 (inactive) antibody, protein tyrosine kinase 7 antibody, PTK7 protein tyrosine kinase 7 antibody, PTK7 antibody, Ptk7 antibody

Background: PTK7 is a member of the receptor tyrosine kinase family, otherwise known as Colon Carcinoma Kinase 4 (CCK4). PTK7 is highly expressed in the kidney, liver, lung, pancreas and melanocytes with weaker expression being detected in the thyroid gland, ovaries, brain, heart and skeletal muscle. PTK7 may play a role in embryonic development. It is thought to function as a cell adhesion molecule and as a novel regulator of the planar cell polarity (PCP) pathway in vertebrates. Studies also suggest that PTK7 may be involved in the tumour progression. A loss of PTK7 expression has been observed in melanoma cell lines, whereas increased levels of PTK7 have been detected in high-throughput acute myeloid leukaemia samples. In addition, PTK7 is not expressed in normal colon but has been detected in colon carcinomas and as such is a potential marker for tumour progression.Synonyms: CCK-4, Colon carcinoma kinase 4, Tyrosine-protein kinase-like 7

Gene ID: 5754

NCBI Accession: NP_002812

UniProt: Q13308

Pathways: RTK Signaling, Tube Formation