DISC1 antibody (Middle Region)

Catalog No. ABIN318901

Product Details anti-DISC1 Antibody

Target: DISC1 (Disrupted in Schizophrenia 1 (DISC1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DISC1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificity: This antibody recognises disrupted in schizophrenia 1 (DISC1), 93 kDa protein located in the nucleus, cytoplasm and mitochondria.

Purification: Antisera to human DISC1 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.

Immunogen: An 18 amino acid peptide located near the centre of human DISC1.

Isotype: IgG

Application Details

Application Notes: Western Blot: 1 - 2g/mL, detects bands of approximately 95100 kDa in SKNSH cell lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline containing 0.02 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for DISC1

Target: DISC1 (Disrupted in Schizophrenia 1 (DISC1))

Alternative Name: DISC1 (DISC1 Products)

Synonyms: DISC1 antibody, C1orf136 antibody, SCZD9 antibody, disrupted in schizophrenia 1 antibody, disrupted in schizophrenia 1 protein antibody, disc1 antibody, DISC1 antibody, LOC100580606 antibody, Disc1 antibody

Background: The DISC1 protein is widely expressed in normal tissues. It is involved in neurite outgrowth and cortical development through its interaction with a variety of proteins including lissencephaly-1 (LIS1), NudeE-like (NUDEL) and phosphodiesterase 4B. In certain cases of schizophrenia the DISC1 gene has been found to be disrupted by a t(1,11) (q42.1,q14.3) translocation, and studies suggest that DISC1 could be a candidate susceptibility gene for this condition.Synonyms: DISC-1, Disrupted in schizophrenia 1 protein, KIAA0457

Gene ID: 27185

NCBI Accession: NP_001012975

UniProt: Q9NRI5

Pathways: Regulation of Cell Size