TACR3 antibody (Middle Region)

Catalog No. ABIN318919

Product Details anti-TACR3 Antibody

Target: TACR3 (Tachykinin Receptor 3 (TACR3))

Binding Specificity: Middle Region

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TACR3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody recognises TACR3 otherwise known as NK3 Receptor (NK3R), a 52.2 kDa multi-pass membrane protein belonging to the G-protein coupled receptor 1 family. This antibody does not recognise NK1R or NK2R.

Purification: Purified

Immunogen: An 18 amino acid peptide from near the centre of Human TACR3.

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry on paraffin sections: 5g/mL, requires antigen retrieval using heattreatment prior to staining of paraffin sections. Western Blot: 0.5 - 1.0g/mL, detects a band of approximately 46 kDa in RAW264.7 celllysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, 0.02 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for TACR3

Target: TACR3 (Tachykinin Receptor 3 (TACR3))

Abstract: TACR3 Products

Synonyms: HH11 antibody, NK-3R antibody, NK3R antibody, NKR antibody, TAC3RL antibody, Nk3r antibody, Nkr antibody, Tac3r antibody, Nmkr antibody, tachykinin receptor 3 antibody, neuromedin-K receptor antibody, TACR3 antibody, LOC100544805 antibody, Tacr3 antibody

Background: TACR3 is a receptor for the tachykinin neuropeptide, neuromedin-k otherwise known as neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Following binding of its ligand, NK3R activates a phosphatidylinositol-calcium second messenger system, and it is likely that these signals lead to the release of vasopressin and oxytocin into the circulation. Studies with mice indicate that TACR3 is involved in learning and memory.Synonyms: NK-3 receptor, NK-3R, NK3R, NKR, Neurokinin B receptor, Neuromedin-K receptor, TAC3R

Gene ID: 6870

NCBI Accession: NP_001050

UniProt: P29371

Pathways: Feeding Behaviour