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ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1) (C-Term) antibody

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Synonyms im:7146264, orai1, tmem142a, zgc:109721, orai2, ORAI1, LOC100218031, CRACM1, ORAT1, TMEM142A, D730049H07Rik, Tmem142a, orai-1, RGD1311873, tmem142b
(52), (22), (16), (15), (11), (10), (3), (3), (2), (2)
Human, Mouse (Murine), Rat (Rattus)
(119), (39), (25), (4), (4), (4), (3), (1), (1)
(85), (20), (14)
(5), (5), (5), (5), (5), (5)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(108), (81), (45), (12), (6), (4), (1)
Pubmed 2 references available
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Quantity 0.1 mg
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Availability Will be delivered in 6 to 8 Business Days
Immunogen A 16 amino acid peptide from near the carboxy terminus of Human ORAI1.
Isotype IgG
Specificity This antibody recognises ORAI1, also known as Transmembrane protein 142A (TMEM142A), a 32.7 kDa multi-pass membrane protein belonging to the ORAI family. This antibody is not expected to cross react with either ORAI2 or ORAI3.
Purification Affinity Chromatography
Alternative Name ORAI1 (ORAI1 Antibody Abstract)
Background Antigen stimulation of immune cells triggers Ca2+ entry through Ca2+ release-activated Ca2+ (CRAC) channels. CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. ORAI1 is a four- transmembrane spanning protein that is an essential component of CRAC. ORAI1 functions as a highly selective Ca2+ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca2+ sensor. Defective ORAI1 in humans is the cause of one form of hereditary severe combined immune deficiency (SCID), which results in ablated T-cell Ca2+ entry.Synonyms: CRACM1, Calcium release-activated calcium channel protein 1, ORAI-1, Protein orai-1, TMEM142A, Transmembrane protein 142A
Gene ID 84876
NCBI Accession NP_116179
UniProt Q96D31
Application Notes Western Blot: 0.5 - 1g/mL, detects a band of approximately 49 kDa in 49 cell lysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS, 0.02 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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Background publications Feske, Gwack, Prakriya et al.: "A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function." in: Nature, Vol. 441, Issue 7090, pp. 179-85, 2006 (PubMed).

Lewis: "Calcium signaling mechanisms in T lymphocytes." in: Annual review of immunology, Vol. 19, pp. 497-521, 2001 (PubMed).

Catalog No. ABIN318921
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