ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3) (N-Term) antibody

Details for Product No. ABIN318923
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Antigen
Synonyms ORAI3, TMEM142C, 9930124N15, BC061259, Tmem142c, RGD1306538
Epitope
N-Term
(25), (24), (7)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(61), (24), (21)
Host
Rabbit
(42), (19)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(61), (44), (22), (10), (7), (6), (1), (1)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN318923
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Immunogen A 15 amino acid peptide from near the amino terminus of human ORAI3.
Isotype IgG
Specificity This antibody recognises human ORAI3, also known as Transmembrane protein 142C (TMEM142C), a 31.5 kDa multi-pass membrane protein belonging to the ORAI family. This antibody is not expected to cross react with either ORAI1 or ORAI2.
Purification Purified
Alternative Name ORAI3
Background Antigen stimulation of immune cells triggers Ca2+ entry through Ca2+ release-activated Ca2+ (CRAC) channels. CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. ORAI3 is one of two mammalian homologs of ORAI1, a four- transmembrane spanning protein that is an essential component of CRAC channels. ORAI3, along with ORAI1 and ORAI2, functions as a Ca2+ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca2+ sensor. Studies indicate that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2.
Alternate names: ORAI-3, TMEM142C, Transmembrane Protein 142C
Gene ID 93129
NCBI Accession NP_689501
UniProt Q9BRQ5
Application Notes Immunohistochemistry on frozen sections: 10g/ml. Western Blot: 1 - 2g/ml, detects a band of approximately 35kDa in A20 cell lysates. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline containing 0.02% Sodium azide
Preservative Sodium azide
Precaution of Use This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Storage 4 °C
Storage Comment Store at +4°C or at -20°C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted.
Expiry Date 18 months
Supplier Images
anti-ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3) (N-Term) antibody anti-ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3) (N-Term) antibody
anti-ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3) (N-Term) antibody (2) anti-ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3) (N-Term) antibody (Image 2)
Background publications Feske, Gwack, Prakriya et al.: "A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function." in: Nature, Vol. 441, Issue 7090, pp. 179-85, 2006 (PubMed).

Mercer, Dehaven, Smyth et al.: "Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1." in: The Journal of biological chemistry, Vol. 281, Issue 34, pp. 24979-90, 2006 (PubMed).

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